Effect of ADX-88178, a highly-selective mGlu4 PAM, on parkinsonism, dyskinesia and psychosis-like behaviours in the MPTP-lesioned marmoset
Objective: To investigate the effect of the metabotropic glutamate 4 (mGlu4) positive allosteric modulator (PAM) ADX-88178 on parkinsonism, dyskinesia and psychosis-like behaviours (PLBs) in the…Anodal transcranial direct current stimulation could change the metabolomic profiles of cerebrospinal fluid in Parkinson’s disease
Objective: We tried to identify meaningful metabolite change after anodal tDCS in clinically diagnosed PD patients by adopting metabolomic analysis Background: Transcranial direct current stimulation…A network imaging biomarker of X-linked dystonia-parkinsonism
Objective: To characterize a metabolic brain network associated with X-linked dystonia-parkinsonism (XDP). Background: X-linked dystonia-parkinsonism (XDP, DYT/PARK-TAF1, Lubag) is an X-linked recessive movement disorder characterized…Correlation between levels of plasma neurofilament light chain and freezing of gait in Parkinson’s disease
Objective: This study evaluated the correlation between neurofilament light chain (NfL) and freezing of gait (FOG) in Parkinson's disease (PD). Background: PD patients frequently experience…Clinical and functional determinants of motor reserve in patients with de novo Parkinson’s disease
Objective: To determine the clinical determinants and the role of serotonergic innervation on motor reserve in patients with de novo Parkinson's disease. Background: Patients with…Timed-up-and-go tests under dual-task conditions: Influence of different tasks on gait parameters in Parkinsonian patients
Objective: To analyse the effect of dual tasking on the Parkinson gait. Background: Parkinson's disease has a strong impact on gait and posture, leading to…Clinical usefulness of tandem gait test for estimating gait and balance in de novo Parkinson’s disease
Objective: The purpose of this study is to objectively evaluate the gait and balance in patients with Parkinson’s disease showing abnormal tandem gait, using three-dimensional motion analysis.…Spiral Tunneling Technique for passing electrode lead for Deep Brain Stimulation(DBS) surgery in Parkinson’s disease(PD)
Objective: To compare the conventional “Twist & Anti-Twist” technique and “Spiral Tunnelling Technique”(STT) for tunnelling the leads for Deep Brain Stimulation surgery in PD. Background:…Acute-onset parkinsonism secondary to bilateral extrapontine myelinolysis of the basal ganglia: case report
Objective: Although rapid osmolar correction, mainly in the setting of hyponatremia is the main risk factor of osmotic demyelination syndrome, the pathogenesis of the syndrome…Genetic outcomes of South Asian Parkinsonism cohort: from a tertiary care hospital
Objective: To identify the genetic heterogeneity in 16 south Asian patient with Parkinson’s disease. Background: Parkinson’s disease(PD) is the second most progressive neurodegenerative disorder with…
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