Five year longitudinal change in the MDS-UPDRS scores in early Parkinson’s disease participants: Results from the PPMI Study
Objective: To determine the longitudinal change in the Movement Disorder Society –Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) in Parkinson’s disease (PD) participants who were untreated…A Phase 3 Study of isradipine as a disease modifying agent in patients with early Parkinson’s disease (STEADY-PD III): Baseline characteristics and study update
Objective: To evaluate the efficacy of isradipine 10 mg daily to slow progression of disability in early PD. Background: Isradipine, a dihydropyridine calcium channel antagonist,…Altered attentional brain network in Parkinson’s disease with mild cognitive impairment
Objective: To investigate alterations in the attention network in Parkinson’s disease patients with mild cognitive impairment (PD-MCI). Background: MCI is a risk factor for dementia…Early caudate involvement in Parkinson’s disease may predict future cognitive decline
Objective: 1. To investigate prevalence of caudate dopaminergic dysfunction as measured by 123I-FP-CIT in a large cohort of early stage (< 2 years disease duration)…The role of phosphodiesterase 4 in sleep disturbances in Parkinson’s disease
Objective: We aimed to assess the association between phosphodiesterase 4 (PDE4) expression and sleep disturbances in vivo using combined multimodal magnetic resonance imaging (MRI) and…Information transfer between subthalamic area and forearm muscles during tonic muscle activity in Parkinson’s patients
Objective: We compare information transfer between forearm muscles and two subthalamic regions, namely the subthalamic nucleus (STN) and the zona incerta (ZI), during an isometric…Calcium Channel Blocking Drugs and Risk of LRRK2 Parkinson’s Disease
Objective: To test the association between Parkinson’s disease (PD) and calcium channel blocker CCB use in individuals carrying LRRK2 mutations. Background: LRRK2 mutation penetrance is…The Superior Colliculus is impaired in de novo Parkinson’s disease patients
Objective: To study the function of the Superior Colliculus (SC) in de novo Parkinson’s disease (PD) patients. Background: The SC function is impaired in parkinsonian…High-Resolution Manometry (HRM) in Parkinson’s Disease (PD)
Objective: To characterize esophageal symptoms in PD using high-resolution Manometry. Background: Dysphagia is common in PD; its etiology multifactorial and its management challenging. In a retrospective…Non-motor symptoms in Parkinsons’s disease patients treated with levodopa-carbidopa intestinal gel infusion- the follow up study
Objective: To follow up the effect of continuous levodopa-carbidopa intestinal gel infusion (LCIG) on motor and non-motor symptoms in advanced Parkinson’s disease (aPD). Background: Non-motor…
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