VY-AADC01 gene therapy in Parkinson’s disease: Interim results of the on-going Phase 1b PD-1101 trial
Objective: Evaluate the safety of VY-AADC01, an AAV2 gene therapy vector with human aromatic L-amino acid decarboxylase (AADC) administered bilaterally to the putamen using intraoperative…CLOVER-DBS: A Prospective, Multi-center Clinical Study with Blinding to Evaluate a Closed Loop Programming Algorithm for Directional Leads Based on External Feedback
Objective: To assess the feasibility and efficacy of a novel closed-loop programming algorithm (CLPA) for directional lead deep brain stimulation (DBS) based on objective feedback…Activities of Daily Living and Quality of Life in Patients with Advanced Parkinson’s Disease Who Are Treated with or Planning to Use Device-Aided Treatments
Objective: To correlate activities of daily living (ADL) and quality of life (QoL) in advanced Parkinson’s disease (APD) patients with ongoing or planned device-aided treatment…Rationale and Design of an Open-Label, Randomized, 26-Week Study Comparing Levodopa-Carbidopa Intestinal Gel to Optimized Medical Treatment on Non-Motor Symptoms in Patients with Advanced Parkinson’s Disease – INSIGHTS Study
Objective: To examine levodopa-carbidopa intestinal gel, LCIG (also known as carbidopa-levodopa enteral suspension in the US), on non-motor symptoms (NMS) compared with individually-optimized, conventional PD…An Objective Tool to Guide Target Selection for DBS in PD (GPi vs STN) – integration into Thomas Jefferson’s multidisciplinary Movement Disorders Center
Objective: After the creation of simple tool to aid in selection of the proper target for Deep Brain Stimulation (DBS) in Parkinson’s Disease (PD), our…Simple Programming Method in STN-DBS using directional lead
Objective: Consider a stimulation programming method that can be performed easily and in a short time. Background: Background: Since the subthalamic nucleus (STN) is a…Outcomes of elective orthopedic surgery in Parkinson’s disease – a Nationwide study
Objective: Provide national outcomes on readmissions after elective orthopedic surgery in Parkinson’s disease (PD). Background: Advances in the treatment of PD have allowed for improvements…Sniffing Parkinson’s in the masses: Volatilome analysis for Parkinson’s Disease diagnostics
Objective: To identify volatile compounds in the skin which can be used to provide an early diagnosis in Parkinson's disease (PD). Background: There is a…Recruitment of Minority populations with Parkinson’s disease at an Urban Hospital
Objective: To evaluate diagnostic disparities in Parkinson’s disease (PD) through recruitment of underrepresented minorities into a PD screening study. Background: African-Americans are less likely than…Reversible Extrapyramidal features as unusual presentation of central pontine myelinolysis: A case report
Objective: To be acquainted with the extrapyramidal symptoms developed during the course of central pontine myelinolysis. To emphasize the importance of neuroimaging in the diagnosis…
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