Diagnostic potential of automated middle cerebellar peduncle volumetry in variants of multiple system atrophy
Objective: To include probabilistic information on the location of the middle cerebellar peduncle (MCP) into an existing subcortical segmentation atlas and to evaluate the diagnostic…Efficacy and safety of safinamide as a levodopa adjunct in patients with parkinson disease and motor fluctuations: A systematic review of randomized controlled trials
Objective: To assess the efficacy and safety of safinamide as an add-on therapy to levodopa in Parkinson patients. Background: Long-term use of levodopa is associated…Inhibition of HDAC4 attenuates rotenone-induced abnormal increase of α-synuclein levels and affects autophagic flux in human dopaminergic SH-SY5Y cells
Objective: To explore the effects of selective inhibition of HDAC4, on levels of α-syn and autophagy-related proteins in PD. To discuss the mechanism for the…A novel mGlu4 PAM alleviates motor symptoms in primate models of PD and of LID
Objective: Objective was to assess the therapeutic potential of our novel mGlu4 positive allosteric modulator (PAM), foliglurax, as an anti-parkinsonian treatment in gold-standard primate models.…The Effect of Conduction Exercise and Self-acupressure in Treatment of Parkinson’s Disease: A Pilot Study
Objective: To evaluate the efficacy and safety of exercise regime combining Conduction exercise (CE) and self-acupressure (SA) in treating both motor symptoms (MS) and non-motor…The Effect of Short Pulse Width Settings on Speech in Subthalamic Nucleus Deep Brain Stimulation for Parkinson’s disease
Objective: To compare perceptual characteristics and intelligibility of speech in Parkinson's Disease (PD) patients with Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) in the acute setting…PLG restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models
Objective: Parkinson disease (PD) is the second most common neurodegenerative disorder after Alzheimer disease and there are few treatments currently available. The present study investigated…Expanding the clinical phenotype of BPAN: A case report
Objective: To describe an atypical presentation of a rare NBIA disorder Background: Beta-propeller protein-associated neurodegeneration (BPAN) manifests in infancy as an initially static encephalopathy with…Efficacy and safety of combined unilateral subthalamic nucleus and contralateral globus pallidus deep brain stimulation in Parkinson’s disease
Objective: To investigate the efficacy and safety of combined unilateral subthalamic nucleus (STN) and contralateral globus pallidus internus (GPi) deep brain stimulation (DBS) in Parkinson’s…Deep brain stimulation in Parkinson’s disease: From the stimulation of a nucleus to the stimulation of neuronal networks
Objective: To evaluate global changes in connectivity of large-scale structural brain networks in Parkinson's disease (PD) patients, and to test the hypothesis that deep brain…
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