Genome-wide association studies of motor and cognitive progression in Parkinson’s disease
Objective: Motor and cognitive progression in Parkinson’s is heterogeneous. Our aim is to identify single nucleotide polymorphisms (SNPs) associated with disease progression. Background: Rare genetic…Effects of N-methyl-D-aspartate receptor antagonist in Parkinson’s disease with dementia
Objective: We conducted this longitudinal study to confirm the efficacy of memantine for PDD by analyzing comparative changes in regional cerebral blood flow (rCBF) and…A comprehensive digital biomarker active testing and passive monitoring suite for the remote and frequent assessment of motor symptom progression in Parkinson’s disease
Objective: We present the development and design of a comprehensive digital biomarker smartphone application (app) for remote and frequent assessments of motor symptom severity and…In vivo MRI signatures of hippocampal subfield pathology in patients with Parkinson’s disease and psychosis
Objective: To study the role of hippocampal subfield pathology in the genesis of psychotic symptoms in patients with Parkinson's disease (PD) by comparing the volumes…Derivation and characterization of Parkinson’s disease related pattern using functional magnetic resonance imaging
Objective: This study attempts to identify Parkinson’s disease-related pattern in Japan using functional magnetic resonance imaging (fMRI), and to characterize this pattern. Background: Parkinson’s disease-related…Objective and quantifiable assessment of sleep in patients with Parkinson’s disease using a wearable sensor
Objective: To explore the feasibility of using a body-fixed sensor (BFS) to assess sleep disturbances in patients with Parkinson's disease (PD), carriers and non-carriers of…Is REM sleep behavior disorder associated with excessive daytime sleepiness in military veterans with Parkinson’s disease?
Objective: To determine if REM sleep behavior disorder (RBD) is associated with excessive daytime sleepiness (ES) in military veterans with Parkinson’s disease (PD). Background: Nearly…Commonalities of prodromal non-motor symptoms between movement disorders
Objective: This study reviewed and compared evidence of nonmotor symptoms in prodromal phases in movement disorders including Parkinson disease, Atypical Parkinsonism (MSA, DLB, PSP), Huntington…Comorbid REM sleep behavior disorder and impulse control disorder symptoms in early parkinson’s disease: The PPMI cohort
Objective: To assess the prevalence of Impulse Control Disorder symptoms (ICD) in Parkinson's disease with probable REM sleep behavior disorder (i.e. RBD assessed by questionnaire,…Cell and animal models lacking RAB39B show biochemical and behavioural phenotypes that model aspects of Parkinson’s disease
Objective: To determine the pathogenic mechanisms underlying RAB39B-mediated Parkinson’s disease (PD). Background: PD is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the…
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