Loss of VPS29 disrupts retromer function and synaptic transmission, leading to neurodegeneration in Drosophila
Objective: To understand the role of the retromer complex in the central nervous system(CNS), and its link to Parkinson's disease (PD) susceptibility. Background: Mutations in…Automated Differential Diagnosis of Parkinsonian Syndromes Using FDG-PET Metabolic Brain Network Analysis
Objective: To discriminate among parkinsonian patients using an automated network analysis of FDG-PET brain images. Background: Clinical differentiating among parkinsonian syndromes: Parkinson’s disease (PD), multiple…Abnormal Functional Connectivity in Cerebellar Locomotor Region is associated with the severity of freezing of gait in patients with Parkinson’s disease
Objective: We aim to analyze cerebellar functional connectivity (FC) in PD patients with FOG (PD-FOG). Background: Freezing of gait (FOG) is a disabling disorder frequently…Semi-automated segmentation and quantification of the substantia nigra depigmentation in Parkinson’s disease – a multicentre case control MRI study in 284 participants
Objective: To provide a semi-automated segmentation and quantification method of the changes in the substantia nigra (SN) in Parkinson’s disease (PD) using neuromelanin (NM)-sensitive MRI…Absence of the nigrosome-1 area in 3 tesla resonance and its relation with hyperechogenicity of the substantia nigra in patients with Parkinson’s disease
Objective: To compare the usefulness of two neuroimaging methods (3TMR and MEcho) to assist in the diagnosis of PD. Background: In patients with Parkinson's disease…α-synuclein propagation via olfactory pathway in non-human primate model
Objective: Recent studies have revealed that intracerebral injection of synthetic α-synuclein (α-syn) fibrils into olfactory bulb (OB) of mice induced prion-like propagation of α-syn aggregates…Smooth muscle dysfunction in the gastrointestinal system in the 6-OHDA model of Parkinson´s Disease
Objective: To explore the connection between the central dopamine system and the autonomous nervous system in GI dysfunction in PD, using animal models. Background: Gastrointestinal…The comparative clinical analysis of sleep patterns in patients with Amyotrophic Lateral Sclerosis and Parkinson’s disease
Objective: We seek to investigate the nighttime sleep pattern of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and primary Parkinson's disease (PD). Background: Sleep disorders…No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors
Objective: We measured NMDA antibodies in a large, well phenotyped sample of Parkinson patients without and with cognitive impairment (n = 297) and controls (n…Tetrahydroisoquinoline Molecule Identified in Traditional Ayurveda Medicine Modulates Inflammation in MPTP Mice
Objective: Potential ‘Anti-parkinsonian’ activity of a tetrahydroisoquinoline (TIQ) molecule of traditional ‘Ayurveda’ medicine was tested in a preclinical MPTP mice model for Parkinson’s disease (PD).…
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