Incidence of drooling in Parkinson’s Disease and Impact on Quality of Life
Objective: The project aimed to determine the frequency and severity of drooling in the Parkinson’s Disease (PD) population in Cardiff & the Vale Health-board through…Impaired lysosomal catabolism of alpha-synuclein in parkinsonian LRRK2(R1441G) mutant mouse embryonic fibroblasts
Objective: Using a unique fluorescence-based flow cytometry assay on LRRK2(R1441G) mutant mouse embryonic fibroblasts (MEFs) to elucidate whether pathogenic LRRK2 mutation affects cellular lysosomal degradation…Attitude of Parkinson Patients towards Participation in Clinical Trials and Brain or Tissue Donation for Research
Objective: A comprehensive survey of patient preferences and attitudes towards clinical trials and tissue donation can help identify and address barriers hindering the recruitment for…Beneficial effect of estrogen on nigrostriatal dopaminergic neurons in drug-naïve postmenopausal Parkinson’s disease
Objective: To investigate the potential beneficial effects of estrogen on nigrostriatal dopaminergic neuron degeneration in postmenopausal drug-naïve Parkinson’s disease. Background: Epidemiologic studies have revealed that…Machine learning classifiers and subjective vocal perception of Parkinson’s disease patients and healthy control
Objective: To identify machine learning classifiers and to assess the acoustic differences between PD patients and healthy control (HC) and the relations between objective and…Phenotypic spectrum of Progressive Supranuclear Palsy in a Tunisian cohort
Objective: To describe the clinical and imaging features of the different phenotypes of progressive supranuclear palsy (PSP). Background: PSP is a neuropathologically defined disease entity…Liquid Levodopa/Carbidopa – An underutilized, cost effective treatment of advanced Parkinson’s disease in the developing world
Objective: Advanced Parkinson’s disease manifests with “on-off” phenomenon, dyskinesias and increasing symptom severity . Managing it in developing countries is difficult given the low per…Retinal thickness and microvascular pattern in early Parkinson’s disease.
Objective: To detect changes in retinal thickness and their possible correlates with microvascular pattern in early PD patients as compared to controls. Background: Physiologically, retinal…Protective effects of β-Nicotinamide Adenine Dinucleotide against motor deficits and dopaminergic neuronal damage in a Parkinson’s disease mouse model
Objective: The aim of our study is to explore whether nicotinamide adenine dinucleotide (NAD) replenishment could be beneficial on a 6-hydroxydopamine-induced Parkinson’s disease (PD) mouse…A First in Human Study of PBT434, a Novel Small Molecule Inhibitor of Alpha-Synuclein Aggregation
Objective: To evaluate the safety, tolerability and pharmacokinetics of PBT434 in healthy volunteers. Background: PBT434 is a novel, small molecule inhibitor of alpha-synuclein aggregation. In…
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