Parkinsonism due to Adult-Onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (ALSP) Responsive to Carbidopa/Levodopa
Objective: To describe a case of Parkinsonism due to ALSP which is responsive to carbidopa/levodopa Background: Adult-Onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (ALSP)…Misdiagnosis of Cognitive Impairment in Parkinson’s disease
Objective: We explored potential bias to diagnose cognitive impairment in People with Parkinson’s (PwP) followed in the Parkinson’s Progressive Markers Initiative (PPMI). Background: In primary…Genome-wide Survival Analysis Identified Association Between HS1BP3 and APOE loci and Dementia in Parkinson’s disease
Objective: We aim to conduct a genome-wide survival study (GWSS) to identify single nucleotide polymorphisms (SNP) associated with dementia in Parkinson’s disease (PD) with a…A phase 2 randomized, double-blind, placebo-controlled trial of Ambroxol as a disease-modifying treatment for Parkinson’s disease dementia.
Objective: To evaluate the safety and tolerability of repurposing Ambroxol as a disease modifying treatment for Parkinson’s Disease Dementia (PDD). Background: Carrying a mutation in…Comparative efficacy of pharmacological cognitive treatments in Parkinson’s disease and Dementia of Lewy Bodies: systemic review & network meta-analysis
Objective: The aim of this study is to evaluate, compare and rank the currently available pharmacological cognitive treatments. Background: Treating cognitive impairment in Parkinson’s disease…Keeping patients out of care facilities— clozapine rescues Parkinson’s patients with troublesome psychosis unresponsive to quetiapine and pimavanserin.
Objective: We describe a single-center cohort of Parkinson patients in crisis with troublesome psychosis unresponsive to quetiapine and pimavanserin, who were rescued by treatment with…How does a diagnosis of Dementia with Parkinson’s influence future care provision?
Objective: To describe the trajectory of Parkinson’s after the onset of dementia including setting of care, frailty levels and mortality rate. Background: Cardiff and Vale…Fibrinogen and CFAH: The two putative markers of Parkinson’s disease with cognitive impairment
Objective: To determine the pathogenic potential of fibrinogen and complement factor H (CFAH) in causing Parkinson’s disease (PD) with cognitive impairment (PDCI)-like symptoms using C57BL/6J…Predicting the development of dementia in patients with Parkinson’s disease by comparing neurosteroids in the blood level
Objective: To increase the reliability of the development of dementia in patients with PD by a comparative assessment of clinical scales and neurosteroids Background: Parkinson's…Data-driven identification of distinct fronto-subcortical and cortical-posterior subtypes of cognitive decline in Parkinson’s disease
Objective: To use a novel data-driven approach, Subtype and Stage inference (SuStain)[1], for identifying distinct subtypes of domain-specific cognitive decline in Parkinson’s disease (PD), and…
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