Using whole genome sequencing and intronic sequence analysis to identify pathogenic variants in Parkin-related Parkinson’s Disease
Objective: To clarify the genetic cause of autosomal recessive early-onset Parkinson’s Disease (EOPD) for which only a single heterozygous coding mutation could be identified. Background:…Deep Brain Stimulation of the Subthalamic Nucleus and Globus Pallidus for apathy in PD patients
Objective: The present meta-analysis was therefore performed to clarify the effects of STN DBS and GPi DBS on apathy. Background: Deep brain stimulation (DBS) of…Dissecting the genetic complexity of Parkinson’s disease: a Parkin-GBA study
Objective: In this study, we investigate how the PD risk factor GBA would affect the cellular phenotypes associated with homozygous mutations in Parkin, causing an…Registration Algorithm of DBS Preoperative Image and ICBM-152 Atlas
Objective: As we all know, there would be some distortions of electrodes or even distortions of patient's brain images when matching the brain atlases with…Detection of genetic modifiers in PRKN
Objective: In this study, we investigate the Hypothesis 1 using Next-generation sequencing (NGS). Background: In 1998, we reported homozygous mutations of PRKN as the causative…Olfactory dysfunction in Parkinson’s disease
Objective: It is to propose a psychophysical test of the olfactory function. Its originality is to use Moroccan odorous products belonging to our culture to…Park-Ease Trial: A Randomized Controlled Trial to Study the Efficacy of Exercises in Early-Stage Parkinson’s Disease
Objective: To evaluate the efficacy of exercises in early-stage Parkinson’s Disease by observing improvement in motor symptoms assessed by Unified Parkinson’s Disease Rating Scale (UPDRS)…SNP assessment and gene expression analysis of alpha-synuclein (SNCA), LRRK2 gene and parkin (PRKN) gene in chewing tobacco exposures and find out the risk of Parkinson’s disease
Objective: We aimed to find out the molecular assessment of the risk of Parkinson’s disease (PD) in tobacco exposure through the SNP and gene expression…How Commonly Does Parkinson’s Disease Present with Dystonia?
Objective: To review dystonia as the presenting feature of Parkinson’s disease (PD). Background: Dystonia in PD is most commonly described as a levodopa complication. It…Screening of mutations in PARK2 gene and Dopamine levels in Parkinson’s disease (PD) patients in Coimbatore population, India
Objective: The aim of the present study was to perform the mutational screening of PARK2 gene and dopamine level in PD patients of Coimbatore population,…
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