Inhibition of nociceptive responses by modulating serotonergic signals at the rostral ventromedial medulla in 6-OHDA-induced Parkinson’s disease rat model
Objective: We aimed to determine whether the descending 5-HT facilitatory pathway from rostral ventromedial medulla (RVM) and the extracellular 5-HT in RVM are involved in…Exploring hospitalizations and visits to the emergency room of patients with Parkinson’s disease: A ten years’ follow-up
Objective: To describe the number and reasons of the visits to the emergency room (ER) and the hospitalizations of Parkinson's disease (PD) patients for a…Exercise induced analgesia is present in people with Parkinson’s disease
Objective: To investigate if exercise-induced analgesia (EIA) is present in people with Parkinson's disease (PD) compared to an age-matched control group. Background: Pain is a…Preclinical evaluation of sub-anesthetic ketamine infusion to reduce L-DOPA-induced dyskinesias: Is it a ‘chemical’ DBS?
Objective: To evaluate mechanism of long-term activity of sub-anesthetic ketamine infusion to reduce L-DOPA-induced dyskinesias (LID). Background: Ketamine is an anesthetic that, when administered as…Neuropsychiatric disturbances in Parkinson’s disease patients’ with chronic pain
Objective: The study objective was to assess the neuropsychiatric profile in Moldavian Parkinson's disease patients with chronic pain. Background: Psychological factors can influence both the…Patient case reports supporting a long-term effect of sub-anesthetic ketamine infusion in reducing L-DOPA-induced dyskinesias
Objective: To evaluate possible long-term anti-dyskinetic activity of low-dose sub-anesthetic ketamine infusion from a retrospective chart review. Background: Repurposing drugs that have already been proven…Unusual motor and non-motor symptoms and signs in the early stage of Parkinson´s disease
Objective: To present unusual motor and non-motor symptoms and signs in the early stage of Parkinson´s disease. Background: Patients with Parkinson´s disease (PD) may present…Osteopathic manipulative treatment in Parkinson’s disease: Preliminary results of a double blind sham-controlled cross-over study
Objective: The primary objective of this study is to quantitatively evaluate the effect of osteopathic manipulative treatment (OMT) in Parkinson's disease. Background: Patients with Parkinson's…Pain correlates with sleep disturbances in Parkinson’s disease
Objective: This study aimed to 1) examine the clinical characteristics of pain in patients with Parkinson's disease(PD) and 2) explore the correlation between pain and…The non-motor side of the honey-moon period of Parkinson’s disease
Objective: To explore the non-motor side of the honey-moon period in Parkinson's disease (PD) and its impact on quality of life (QoL). Background: Although there…