Neurogenic orthostatic hypotension is not associated with generalized dysautonomia in early motor PD
Objective: We aim to assess the relationship between neurogenic Orthostatic Hypotension (nOH) and general dysautonomia in an early motor PD cohort. Background: Dysautonomia is a…Orthostatic vital sign changes do not influence 5-year motor outcomes in PD
Objective: We assessed whether orthostatic blood pressure (BP) and heart rate (HR) changes in an early motor PD cohort influence motor, and postural instability and…Neurogenic Orthostatic Hypotension in Parkinson’s Disease: Is there a role for Locus Coeruleus Magnetic Resonance Imaging?
Objective: To test whether degeneration of the Locus Coeruleus (LC) is associated with Orthostatic Hypotension (OH) in Parkinson’s disease (PD).To test whether degeneration of the…A multiple-dose thorough QT study to evaluate the effect of ampreloxetine on cardiac repolarization in healthy subjects
Objective: To characterize the effect of therapeutic and supratherapeutic doses of ampreloxetine on cardiac repolarization in healthy subjects. Background: Ampreloxetine is a potent NE reuptake…Levodopa-induced orthostatic hypotension in a large cohort of patients with Parkinson’s disease undergoing an acute levodopa challenge test
Objective: We aimed to investigate the frequency and associated risk factors for Levodopa-induced orthostatic hypotension (OH) in a large cohort of PD patients underwent acute…Impact of orthostatic hypotension with sleep disturbance on cognition
Objective: To define features of cognitive decline in a group of patients with orthostatic hypotension combined with sleep disorders. Background: recent data suggest that orthostatic…An Analysis of Subgroups of Multiple System Atrophy Patients from Ampreloxetine Phase 3 Trials
Objective: To present results in the subset of patients with multiple system atrophy (MSA) and relevant MSA subgroups from two ampreloxetine phase 3 trials for…Machine Learning Model for Prediction of acute orthostatic hypotension after levodopa administration
Objective: The aim of this study is to develop and validate a prediction model of AOHPL to facilitate physicians in identifying patients at higher probability…Myocardial sympathetic denervation biomarkers for early detection of prodromal DLB
Objective: Because of the time course of detecting DLB symptoms and signs, DLB is poorly diagnosed and hardly differentiate from AD, especially in early stage…Genetics of Neurogenic Orthostatic Hypotension in Parkinson’s Disease
Objective: We examined the association between NOH and PD-related Single Nucleotide Polymorphism (SNPs) and mapped their effects on gene expression and metabolic and signaling pathways.…
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