Parkinson Progression Marker Initiative 2.0 – New Science/New Cohorts
Objective: The Parkinson Progression Marker Initiative 2.0 (PPMI 2.0) is a longitudinal, observational, multi-center natural history study to assess progression of clinical features, digital outcomes,…Olfactory impairment in Wilson’s disease
Objective: Olfactory dysfunction is a very common and early sign of many neurodegenerative disorders, but little is known about olfactory dysfunction in Wilson’s disease (WD).…Assessing the screening performance of three abbreviated smell tests in Parkinson’s disease
Objective: We aimed to: a) determine the effectiveness of two shortened six-item ‘scratch-and-sniff’ smell tests and an alternative novel alginate capsule scent delivery system in…Improving estimation of Parkinson’s disease risk – enhancing the PREDICT-PD algorithm
Objective: To develop and test an enhanced algorithm for the prediction of Parkinson’s disease (PD) risk. Background: The PREDICT-PD algorithm estimates risk of PD using…Hyposmia as a biomarker in patients with Parkinson’s disease and atypical Parkinsonism
Objective: To investigate neural correlates associated with olfactory dysfunction using fMRI and EEG in Parkinsonism. Background: Patients with Parkinsonism experience non-motor symptoms during the onset…The role of dopamine mis-metabolism in preclinical Parkinson’s disease olfactory deficits
Objective: To gain an understanding of the underlying pathological mechanisms of Parkinson’s disease (PD)-related hyposmia using post-mortem human olfactory bulbs and an in vivo model…Difference in olfactory impairment between tremor dominant and akinetic rigid dominant Parkinson’s disease patients
Objective: To investigate difference in olfactory impairment between tremor dominant (TD) and akinetic rigid dominant (ARD) Parkinson’s disease patients. Background: PD can be classified in…Diagnostic value of olfactory dysfunction in Parkinson’s disease
Objective: To assess the olfactory performance in patients with PD using “Sniffin’ Sticks”. Background: Olfactory dysfunction is an important early premotor biomarker for PD, and…Odor Identification as a Biomarker of Incident Cognitive Impairment and its Correlation with Neuropathology in the Rush MAP
Objective: Evaluate the neuropathological correlates and prospective incident cognitive and motor changes associated with odor identification (OI) in cognitively normal (CN) subjects. Background: Hyposmia is…Retronasal olfactory function in Parkinson’s disease
Objective: The objective of this study was to compare orthonasal and retronasal olfactory function in PD patients and compare them to NPOD participants and to…
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