Seeking regulatory feedback on novel clinical outcome assessments: a case example from the Huntington’s Disease – Regulatory Science Consortium (HD-RSC)
Objective: To align with regulators on the utility and development strategy of novel clinical outcome assessments for use in Huntington’s disease (HD) clinical trials. Background:…Drooling in Parkinson’s Disease: A [123I]FP-CIT SPECT study
Objective: Evaluate the association between drooling and striatal dopamine terminals. Test the assumption that drooling correlates with disease progression in de novo Parkinson’s disease (PD)…The influence of physical activities on cognition in small group of Parkinson’s Disease patients
Objective: To assess the relation between cognitive performance and physical exercise in Parkinson's Disease patient. Background: Cognitive deficit is a common non-motor symptom in PD,…Non motor fluctuations in Parkinson’s disease: Findings from a Tunisian cohort
Objective: To evaluate the frequency of non motor fluctuations (NMF) in Parkinson's disease (PD), their correlation with motor complications and their impact on the quality…Relationship between striatal dopamine depletion and various non-motor symptoms in non-demented patients with Parkinson’s disease: a pilot study
Objective: We aimed to investigate associations of striatal dopamine uptake and various non-motor symptoms in non-demented patients with Parkinson’s disease (PD). Background: Dopamine transporter (DAT)…Effect of opicapone in Parkinson’s disease patients with ‘early’ motor fluctuations: Parkinson’s Disease Questionnaire (PDQ-39) analysis from the BIPARK-I double-blind experience
Objective: To evaluate the impact of opicapone (OPC) on PDQ-39 in levodopa-treated Parkinson’s Disease (PD) patients with ‘early’ motor fluctuations. Background: OPC, a once-daily COMT…African American patients with Parkinson’s disease: A hospital-based study compared to Caucasian patients
Objective: To characterize the demographic, socioeconomic, clinical and healthcare features of African American (AA) patients with Parkinson’s disease (PD) compared to Caucasian PD patients in…Motor and non-motor symptoms related to sleep disturbances in Parkinson’s disease
Objective: To assess which (non-)motor symptoms are associated with the longitudinal development of sleep disturbances, one of the major non-motor symptoms (NMS) in Parkinson’s disease…(Not) sleeping with the enemy: Cognitive correlates of nocturnal sleep disturbances in Parkinson’s disease
Objective: To evaluate cognitive correlates of nocturnal sleep dysfunction in patients with idiopathic Parkinson’s disease (PD). Background: Sleep disturbances are among the most troublesome and…Mindfulness Based Stress Reduction in People with Parkinson’s Disease and their Carepartners
Objective: To assess the feasibility and impact of mindfulness based stress reduction (MBSR) on people with Parkinson’s disease (PD) and their carepartners. Background: Non-motor symptoms…
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