MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Nigrostriatal dopaminergic synapse deficiency"

  • 2017 International Congress

    Non-Progressive Coreoatethosis Secondary to Infantile Necrotizing Encephalopathy Mimicking Leigh Disease.

    G. Fabiani, H. Teive (Curitiba, Brazil)

    Objective: Our objective is to report  image findings of an acute necrotizing encephalopathy of childhood (ANEC) in a 15 years-old girl, completely normal until 18…
  • 2016 International Congress

    Motor rigidity selectively associates with impaired odor identification in Parkinson’s disease

    J.D. Haugen, M.L.T.M. Muller, V. Kotagal, K.A. Frey, R.L. Albin, N.I. Bohnen (Ann Arbor, MI, USA)

    Objective: To investigate the relationship between impairments of the cardinal motor symptoms and odor identification deficits in Parkinson's disease (PD). Background: Although hyposmia has been…
  • 2016 International Congress

    Comparative study of the substantia nigra echogenicity and 123-I ioflupane SPECT in patients with REM behavior disorder

    J. Mašková, P. Dušek, D. Školoudík, K. Kupka, K. Šonka, V. Ibarburu Lorenzo Y Losada, J. Kubinyi, E. Ruzicka (Praha 2, Czech Republic)

    Objective: To compare (1) the echogenicity of substantia nigra (SN) in subjects with idiopathic REM behavior disorder (iRBD) and healthy controls and (2) to determine…
  • 2016 International Congress

    Dat-SPECT in multiple system atrophy (MSA)

    I. Toyoshima, T. Hatakeyama, Y. Takeda, K. Obara, M. Kobsysdhi, C. Wada (Yurihonjo, Japan)

    Objective: To evaluate the extent of degeneration in dopamine nerve terminal in striatum with the patients with MSA, and compared between subtypes and disease duration…
  • 2016 International Congress

    Localization and functional study of synaptic vesicle protein synaptogyrin-3 (SYNGR3) on dopaminergic neuronal system

    L.F. Li, P.W.L. Ho, H.F. Liu, Z.H.M. Tse, C.S.C. Lam, M.C.T. Leung, M.H.W. Kung, D.B. Ramsden, S.W.L. Ho (Hong Kong, People's Republic of China)

    Objective: To investigate (1) the intracellular localization of SYNGR3 and its interaction with dopamine transporter (DAT); (2) how expression of SYNGR3 in neurons affects dopamine…
  • 2016 International Congress

    Dissecting the molecular mechanisms of Fyn-mediated levodopa induced dyskinesias

    M.P. Bordone, M.A. Bernardi, A. Damianich, S. Sanz-Blasco, G. Gómez, I.R.E. Taravini, M.E. Avale, O.S. Gershanik, J.E. Ferrario (Buenos Aires, Argentina)

    Objective: To investigate the crosstalk between D1 receptor (D1R) and the signaling of Fyn protein kinase in a mice model of levodopa (L-DOPA) induced dyskinesias…
  • 2016 International Congress

    Neurodegeneration and microgliosis are independent of α-synuclein aggregation in a mouse model of "prion-like" α-synuclein speading

    P. Garcia, W. Wemheuer, S. Brioschi, A. Masuch, E. Masliah, V. Koziel, T. Pillot, E. Koncina, C. Jaeger, A. Weihofen, R. Balling, K. Biber, M. Buttini (Esch-sur-Alzette, Luxembourg)

    Objective: Our aim was to test if α-synclein aggregation drives neuronal demise and microglial activation in a murine model of induced-α-synucleinopathy. Background: Pathological α-synuclein aggregates…
  • 2016 International Congress

    Striatal PDE10 expression in Parkinson’s disease (PD) and healthy controls using [18F]MNI-659 PET imaging

    D.S. Russell, D.L. Jennings, O. Barret, G.D. Tamagnan, D. Alagille, J.P. Seibyl, K.L. Marek (New Haven, CT, USA)

    Objective: To evaluate the feasibility of [18F]MNI-659 PET, a striatal PDE10A imaging tracer, as a imaging biomarker in PD. Background: PDE10 is highly and specifically…
  • 2016 International Congress

    The association between structural brain connectivity with plasma APO-A1 levels in Parkinson’s disease: Connectometry approach

    F. Rahmani, M.H. Aarabi (Tehran, Islamic Republic of Iran)

    Objective: Features of the lipid profile specially cholesterol levels are association with PD risk. However no such data exists on the association of these plasma…
  • 2016 International Congress

    Nigrostriatal degeneration and serum BDNF levels in patients with “de novo” untreated Parkinson’s disease

    G. Marti, N. Saez, M. Corominas, G. Cuberas, C. Lorenzo, O. De Fabregues, J. Alvarez-Sabin, M. Casas, J. Hernandez (Barcelona, Spain)

    Objective: To evaluate serum Brain-Derived NeurotrophicFactor(BDNF) levels in “de novo” untreated Parkinson's disease (PD) patients and their relationship to nigrostriatal degeneration measured with [123I]FP-CIT SPECT.…
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