DAT-SPECT in old onset Parkinson’s disease: should we trust?
Objective: . Background: Scans without evidence of dopaminergic deficit (SWEDD) refers to patients clinically diagnosed with Parkinson’s disease (PD), but show normal findings on dopamine…Progression of nigrostriatal dysfunction in Parkinson’s disease: a longitudinal multimodal PET study
Objective: To investigate the longitudinal course of nigrostriatal metabolic and dopaminergic dysfunction and its impact on symptom severity in Parkinson's disease (PD) patients using a…Eyelid opening apraxia as the first manifestation of Creutzfeldt- Jakob disease with 99mTc-TRODAT-1 brain SPECT study
Objective: Our objective is to report a case of sporadic CJD (CJD) in a 57-years-old male patient. It started with severe insomnia followed by eyelid…Sex-related longitudinal change of motor features and biological biomarkers in early Parkinson’s disease from the PPMI cohort
Objective: We aim to describe sex-related longitudinal changes in (1) motor features and motor aspects of experiences of daily living and (2) biologic measures as…Increased expression of conexin 36 in rodent model of Parkinson disease
Objective: To evaluate changes in non-synaptic mechanisms associated with the procedures to reproduce the neurophysiological conditions typical of Parkinson's disease (PD). Background: Many mechanisms that…Alpha-synuclein preformed fibril (PFF)-triggered synucleinopathy recapitulates neurochemical features of human PD: A PET study in rats
Objective: To investigate longitudinal dopaminergic deficits and similarity to human Parkinson’s disease (PD) using PET imaging in the rat alpha-synuclein (a-syn) preformed fibril (PFF) model.…Genetic Profiling of Early Synucleinopathy in Rat Nigrostriatal Dopamine Neurons
Objective: Identification of changes in gene expression in rat nigral neurons associated with early phases of synucleinopathy. Background: Early phases of synucleinopathies such as Parkinson’s…In vivo imaging of presynaptic terminal loss in early Parkinson’s disease
Objective: To determine the magnitude and anatomical extent of presynaptic terminal damage in early Parkinson’s disease (PD) in vivo, we performed a PET study with…Correlation between striatal CIT uptake and Mini-Mental State Examination in Parkinson’s disease
Objective: This study was performed to identify any relationship between the amount of decline of receptor uptake of CIT and Mini-Mental State Examination(MMSE) score in…Therapeutic intervention of LRRK2 kinase inhibitors in Vps35 p.D620N Parkinsonism
Objective: To explore the therapeutic potential of LRRK2 kinase inhibitors in a Vps35 p.D620N mouse model of Parkinsonsim. Background: The discovery of a missense mutation, Vps35 p.D620N…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.