Minimal impact of “interleaving” on neuromodulation device battery drain when interleave frequency is halved
Objective: To contrast neurostimulator battery decay subsequent to the implementation of interleaving with that prior to interleaving. Background: Neurostimulators permit “interleaving”, which allows different same-lead…Impulsive action tendencies in GPi DBS Parkinson’s patients
Objective: To test the effects of GPi DBS on susceptibility to impulsive action errors and the proficiency of reactive inhibitory control to counteract interference from…Improvement of impulse control disorder in Parkinson’s disease patients treated with subthalamic nucleus stimulation
Objective: To find effects of subthalamic deep brain stimulation on impulse control disorder in patients with Parkinson's disease. Background: Parkinson's disease (PD) is a common…Baseline physical activity may influence exercise-induced changes in cognitive function in Parkinson’s disease
Objective: To determine how physical activity (PA) levels influence disease severity and cognitive function changes as a result of exercise in Parkinson's disease (PD). Background:…Identification of unique metabolite signatures in post-mortem DBS human tissue using LC-HRMS
Objective: Metabolomics is applied to the study of metabolic as well as neurodegenerative diseases. We propose to utilize this technique to detect metabolic changes from…Long-term results of pallidal deep brain stimulation in a cohort of eight children with isolated dystonia assessed by blinded video rating
Objective: We present long-term results up to 13 years in a consecutive series of 8 pediatric patients assessed with blinded video rating. Background: : The…Electric stimulation of the nucleus subthalamicus is able to modulate prepulse inhibition. A pilot study in Parkinson´s disease
Objective: To evaluate if prepulse inhibition (PPI) is influenced by electrical stimulation in the Nucleus subthalamicus (STN) of patients with Parkinson´s disease (PD). Background: PPI…VANTAGE trial: Three year outcomes of a prospective, multi-center trial evaluating deep brain stimulation with a new multiple-source, constant-current rechargeable system in Parkinson’s disease
Objective: The VANTAGE study assesses motor improvement in moderate-to-severe Parkinson's disease (PD) following bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) using a new, implantable,…Comparison of four DBS lead designs under voltage and current operating modes based on patient specific simulations
Objective: To quantitatively compare the spatial extension of the electric field generated by four different lead designs operated under voltage and current modes. Background: Conventional…DIRECT DBS: A prospective, multi-center clinical trial with blinding for a directional DBS lead
Objective: DIRECT DBS is an exploratory study which will investigate the effects of subthalamic deep brain stimulation (DBS) using directional DBS leads with current steering…