Deep brain stimulation contact selection using Neurophysiology and Artificial intelligence
Objective: To develop a machine learning (ML) algorithm capable of predicting the optimal deep brain stimulation (DBS) contact based on neurophysiology. Background: DBS is an…Optogenetic Deep Brain Stimulation Rescues Motor Behavior in a Rat Model of Mild Parkinson’s Disease
Objective: To demonstrate feasibility and proof-of-concept for a bilateral rat model of Parkinson’s disease (PD) undergoing deep brain stimulation (DBS) of the subthalamic nucleus (STN)…Reaching Kinematics in Movement Disorder Patients Using an Open-Source Computer Vision Technology
Objective: In this study, we compared kinematic parameters of reaching task between SCA12 and healthy control participants using a novel tracking device. Background: Reaching for…Basal ganglia theta oscillation as a predictor of levodopa-induced dyskinesias
Objective: To investigate the temporal and spatial relationship between local field potential (LFP) changes and dyskinesia development. Background: Levodopa-induced dyskinesias (LID) are an important burden…Cortical activity during visually perturbed gait in older adults
Objective: The primary aim of this preliminary study was to explore pre-frontal cortex (PFC) and posterior parietal cortex (PPC) activity in older adults (OAs) during…Exploring the neural correlates of impulsivity and impulsive compulsive behaviors in Parkinson’s disease
Objective: To explore the subcortical neural correlates of impulse control and related behavioral disorders (ICBD) and trait impulsivity in a chronic and naturalistic setting in…Sex Cerebral Vasoreactivity Differences in Parkinson’s Disease: Uncovering the Tip of the Iceberg
Objective: To determine sex differences in cerebral vasoreactivity (cVR) in patients with Parkinson’s disease (PD) and its association with the clinical spectrum of the disease.…Monopolar sensing improves the efficiency of DBS programming in Parkinson’s disease
Objective: Compare the clinical outcomes of optimal settings between in-clinic monopolar sensing (MS) and standard of care monopolar review (MR) for deep brain stimulation in…Feasibility and added value of sensing feature in patients with chronic STN DBS for Parkinson’s disease
Objective: To test the feasibility and usefulness of sensing features in patients undergoing replacement of their implantable pulse generator (IPG). Background: People with Parkinson’s disease…Neuropeptide Alterations in Parkinson’s Disease: A Meta-Analysis
Objective: To analyze the levels of different neuropeptides in patients with Parkinson’s disease (PD) compared to healthy individuals. Background: Neuropeptides are bioactive molecules that play…
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