Nigrostriatal degeneration and serum BDNF levels in patients with “de novo” untreated Parkinson’s disease
Objective: To evaluate serum Brain-Derived NeurotrophicFactor(BDNF) levels in “de novo” untreated Parkinson's disease (PD) patients and their relationship to nigrostriatal degeneration measured with [123I]FP-CIT SPECT.…Proprioceptive training as a means to enhance sensorimotor function in Parkinson’s disease
Objective: To identify whether proprioceptive function in Parkinson's disease (PD) can be enhanced by specialized visuomotor training that emphasizes precise movements and determine if such…Parkinson’s disease motor subtypes show similar deficits in inhibitory control
Objective: To determine whether predominant motor subtypes of Parkinson's disease (PD) differentially impact distinct forms of inhibitory motor control. Background: Parkinson's disease (PD) impairs rapid…Levodopa induced dyskinesia and nicotinergic α4β2 acetylcholin receptor density: A multi-tracer imaging study
Objective: We investigated α4β2 acetylcholin receptor (nAChR) density in subjects with Parkinson's disease (PD) with and without levodopa-induced dyskinesia (LID) and its correlation with dopaminergic…Floor square size predicts step count of 360° turns in PD patients with freezing
Objective: To determine the effect of floor square size on turning behavior in patients with PD. Background: Turning has been repeatedly shown to be the…Diffusion tensor imaging in Parkinson’s disease: Review and meta-analysis with clinical considerations and neuroimaring parameters
Objective: (1) To synthesize brain white matter changes with diffusion tensor imaging (DTI) in Parkinson's disease (PD); and (2) to study correlations of these changes…Subthalamic nucleus activity during virtual reality provoked lower limb freezing in a patient with Parkinson’s disease and freezing of gait
Objective: Record subthalamic nucleus activity in a Parkinson's disease patient with gait freezing while they perform a virtual reality walking task during DBS surgery. Background:…Movement related beta oscillatory activity during self-paced wrist movement in the human subthalamic nucleus
Objective: To explore voluntary movement related neuronal activity in the subthalamic nucleus in patients with Parkinson's disease (PD). Background: How the human basal ganglia processes…Distribution of oscillatory activities in MRI confirmed subthalamic nucleus subregions
Objective: To explore the differences and similarities of oscillatory activity between subregions of the subthalamic nucleus (STN). Background: In Parkinson's disease (PD), treatment driven changes…Effect of vibration on motor performance: A new intervention to improve bradykinesia in Parkinson’s disease?
Objective: Here we propose to test whether bradykinesia in Parkinson's disease (PD) can be ameliorated by non-invasive interventions (peripheral tactile vibration) that decrease sensory precision.…