Postural and nonmotor disturbances in Parkinson’s disease
Objective: To investigate postural impairments (PI) and their interrelation with non-motor symptoms in patients with Parkinson's disease (PD). Background: PI mechanisms are only partially known.…Stage dependent alteration of cortical excitability in patients with hepatic encephalopathy
Objective: To evaluate cortical excitability in patients with hepatic encephalopathy (HE) using transcranial magnetic stimulation (TMS). Background: HE is a neuropsychiatric disorder manifesting with movement…Cerebellar learning and its modifiability by alcohol in myoclonus-dystonia
Objective: To investigate cerebellar learning and its modifiability by alcohol in SGCE mutation-positive M-D using eye blink conditioning (EBC). Background: M-D is characterized by generalized…Astroglia exert a neuro-protective role in Parkinson’s disease by reducing oxygen stress through dopamine-induced activation of the pentose-phosphate pathway
Objective: Although dopaminergic neurons themselves take up most of the released dopamine (DA), a part of the DA appears to be taken up by astroglia.…Single unit activity of medial thalamus during goal-directed motor and cognitive behavior in patients with cervical dystonia
Objective: To 1) study neuronal activity of medial thalamic nuclei (MD, CM-Pf) and its role in cognitive and motor human activity and 2) evaluate neuronal…Investigating the plastic effects of rapid paired associative stimulation in dystonia
Objective: To investigate the effects of rapid paired associative stimulation (PAS) in organic and psychogenic dystonia to see if this technique can differentiate them. Background:…Localization and functional study of synaptic vesicle protein synaptogyrin-3 (SYNGR3) on dopaminergic neuronal system
Objective: To investigate (1) the intracellular localization of SYNGR3 and its interaction with dopamine transporter (DAT); (2) how expression of SYNGR3 in neurons affects dopamine…Automatic event-detection for the neurophysiological evaluation of voluntary and involuntary movements
Objective: This project aims at creating a tool for automatic EMG event- detection to support clinicians in this process. Background: Neurophysiological evaluation of voluntary and…AMP kinase regulates ligand-gated K-ATP channels in substantia nigra dopamine neurons
Objective: To characterize the effect of AMP-activated protein kinase (AMPK) on ATP-sensitive K+ (K-ATP) channels on substantia nigra compacta (SNC) dopamine neurons in slices of…A whole brain anatomical network model and its application in PD research
Objective: To build a frame of whole brain anatomical network for incorporating different data from different studies with different brain parcellations and resolutions, to evaluate…
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