Brainstem reflexes in patients with neuroleptic-induced akathisia
Objective: We aimed to investigate brainstem reflexes in patients with akathisia. Background: Akathisia is characterized by urge, inner restlessness and constant movement of predominantly lower…The novel Parkinson´s disease locus RIT2 and alpha-synuclein function in intersecting pathways
Objective: We aim to describe the molecular pathways at the crossroad of etiology and susceptibility in PD, focusing on Rin, coded by the recently associated…Cortical excitability during a movement compared with postural control task in healthy subjects
Objective: To investigate cortical excitability and surround cortical inhibition during movement compared with postural control task in healthy subjects. Background: Motor control has traditionally been…Firing rate and proportion of subthalamic oscillatory neurons increase associated with more advanced Parkinson’s Disease
Objective: To explore whether neuronal firing rate and proportion of oscillatory neuronal activity in the subthalamic nucleus (STN) is associated with severity in patients with…Subcortical involvement in body and mental action processing: an electrophysiological registration study
Objective: The current research project focusses on the electrophysiological registration of semantics (body versus mental action verbs) within the thalamus, subthalamic nucleus (STN) and the…Targeted overexpression of A53T-alpha-synuclein induces progressive neurodegeneration and electrophysiological changes of noradrenergic locus coeruleus neurons – a preclinical model of Parkinson’s disease
Objective: In our present study, we developed a new mouse model to study the time dependent effects of cellular A53T-α-synuclein overexpression in the locus coeruleus,…Medication optimization in Parkinson’s disease patients with ON-state freezing using objective gait assessments
Objective: To determine whether objective gait assessments could guide therapeutic decision making in Parkinson’s disease (PD) patients reporting freezing of gait (FOG) in the levodopa-ON…Listen to your heart: ordinal pattern statistics reveal altered cardiac rhythm dynamics in LRRK2-nonmanifesting carriers
Objective: To assess the complexity of heart rate variability (HRV) dynamics in LRRK2-nonmanifesting carriers compared to healthy individuals. Background: Cardiovascular autonomic dysfunction is an early…Oscillatory Activity in the Nucleus Basalis of Meynert
Objective: Characterize oscillatory activity in and around the nucleus basalis of Meynert (NBM). Background: The NBM is the major source of cholinergic innervation to the…Impaired intracortical inhibition is associated with reduced hand dexterity in Parkinson’s disease patients
Objective: To check whether hand dexterity in Parkinson’s disease (PD) patients is linked with motor cortex excitability and plasticity. Background: Hand dexterity is impaired in…
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