Remote patient monitoring with a digital biomarker approach generates clinically distinctive and meaningful sensor feature data in Parkinson’s disease: Differential relationships with MDS-UPDRS-III, PDQ-39 and DaT-SPECT
Objective: To determine whether sensor features derived from remote smartphone testing in Parkinson’s disease (PD) predicted clinical, quality of life and biomarker measures collected in…Evaluation of bradykinesia in Parkinson’s disease using a computerised evolutionary algorithm
Objective: Application of a computerised algorithm to kinematic motor recordings to distinguish parkinsonian bradykinesia from normal movement. Background: Bradykinesia, the only obligatory physical sign for…Beta burst coupling across the motor circuit in patients with Parkinson’s disease
Objective: Here, we test the hypothesis that beta bursts not only involve dynamically elevated local synchronisation but also distributed coupling across circuit nodes, further restricting…Pallidal beta bursts in Parkinson’s disease and Dystonia
Objective: The aim of this study is to test whether prolonged beta burst duration is disease-specific for Parkinson's disease when compared to oscillatory activity in…Relationship of Vitamin D deficiency with Parkinson’s disease risk
Objective: To study the level of vitamin D in the serum of Parkinson’s disease patients in the involvement of disease risk. Background: The Parkinson’s disease…Intracortical plasticity is preserved in de novo Parkinson’s disease: a tSMS study.
Objective: To test the intracortical plasticity of motor cortex in treatment-naïve (de novo) patients with Parkinson’s disease (PD), by means of transcranial static magnetic field…Beta oscillatory changes during practice and retention of motor skills in healthy subjects and patients with PD
Objective: The objective is to define the relationship between increase in beta oscillatory changes with practice and retention of motor skills in normal healthy subject…Efficient control of dopamine neuron physiology for rescuing disease phenotypes
Objective: Dopamine neurons (DAs) of the substantia nigra degenerate in Parkinson's disease and are disrupted in Huntington's disease. Here we propose single cell computational modeling…Objective gait parameters as a noninvasive biomarker for freezing of gait in Parkinson’s disease patients
Objective: To determine if steady-state gait parameters in Parkinson disease (PD) patients could serve as a predictive biomarker for freezing of gait (FOG). Background: FOG…The AppTUG : a new application for analyzing the Timed Up and Go task in patients with neurological disorders
Objective: To perform an initial validation of a newly developed smartphone-based Timed Up & Go (TUG) application (AppTUG), by comparing its measurements to the stopwatch-measured…
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