The utility of electrophysiological tests in the differentiation of upper limb tremor in young-onset patients
Objective: To explore the diagnostic utility of neurophysiologic tests in young-onset patients who present primarily with upper limb action tremor. Background: In young-onset patients, isolated…Closed loop spinal cord stimulation restores locomotion and desynchronizes corticostriatal beta oscillations
Objective: To test if closed loop Spinal Cord Stimulation (SCS) could be used to restore locomotion in a 6-hydroxydopamine (6-OHDA ) rodent model of Parkinson's…Long-term and dopamine dependent dynamics of subthalamic nucleus local field potentials in Parkinson’s disease
Objective: Using a new deep brain stimulation (DBS) pulse generator device that can record local field potentials (Activa PC+S, Medtronic Inc.), the current experiment investigated…Remote patient monitoring with a digital biomarker approach generates clinically distinctive and meaningful sensor feature data in Parkinson’s disease: Differential relationships with MDS-UPDRS-III, PDQ-39 and DaT-SPECT
Objective: To determine whether sensor features derived from remote smartphone testing in Parkinson’s disease (PD) predicted clinical, quality of life and biomarker measures collected in…Evaluation of bradykinesia in Parkinson’s disease using a computerised evolutionary algorithm
Objective: Application of a computerised algorithm to kinematic motor recordings to distinguish parkinsonian bradykinesia from normal movement. Background: Bradykinesia, the only obligatory physical sign for…Beta burst coupling across the motor circuit in patients with Parkinson’s disease
Objective: Here, we test the hypothesis that beta bursts not only involve dynamically elevated local synchronisation but also distributed coupling across circuit nodes, further restricting…Pallidal beta bursts in Parkinson’s disease and Dystonia
Objective: The aim of this study is to test whether prolonged beta burst duration is disease-specific for Parkinson's disease when compared to oscillatory activity in…Relationship of Vitamin D deficiency with Parkinson’s disease risk
Objective: To study the level of vitamin D in the serum of Parkinson’s disease patients in the involvement of disease risk. Background: The Parkinson’s disease…Red cell distribution with levels in Parkinson’s disease patients
Objective: Parkinson’s Disease is a neurodegenerative disorder caused by oxidative stress, protein changes and mitochondrial disfunction. Lately, it has been suggested that inflammatory cytokine levels…Cortical myoclonus explained by cerebellar dysfunction: Evidence from a unique case
Objective: To give a thorough neurophysiological description of a patient presenting with unilateral cortical myoclonus and homolateral congenital cerebellar hemiatrophy Background: The role of the…
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