Increased vesicular monoamine transporter alleviate MPTP-induced impairment of neurogenesis
Objective: In this study, we employed vesicular monoamine transporter 2–overexpressing mice (VMAT2-HI) to investigate the influence of increased vesicular storage of catacholamines on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced…Gastrointestinal disorders in various forms of parkinsonism
Objective: To examine the types of gastrointestinal disorders in parkinsonism, depending on the form of the disease. Background: One of the non-motor autonomic disorders of…Dopaminergic stem cells reside in the rostral migratory stream
Objective: To analyze if the adult rostral migratory stream (RMS) harbors neural stem cells with the potential to create dopaminergic neurons for the olfactory bulb…Relationship between cyclooxygenase-2 gene polymorphisms and Parkinson’s disease susceptibility in Chinese Han population
Objective: To investigate relationship between the cyclooxygenase-2 (COX-2) gene promoter region (rs20417, rs689466, rs689465) and 3'untranslated region (rs5275) polymorphisms with Parkinson’s disease (PD) susceptibility in…CB2R agonist AM1241 reverses the development of MPTP-induced PD and activates the regeneration of DA neurons
Objective: A promising and potential direction to treat PD is to develop new non-dopaminergic drugs without producing dyskinesia, as well as arresting and even reversing…Expression of OX40 and OX40 serum level in patients with Parkinson’s disease
Objective: Study the expression of OX40 gene and its serum levels could be measured to predict and confirm diagnosis of Parkinson's disease and help develop new…Impaired hippocampal neurogenesis associates with serotonergic axonal degeneration in transgenic rat and mouse models of Parkinson’s disease
Objective: To evaluate the impact of α-synuclein accumulation on the hippocampal serotonergic system and hippocampal plasticity in two different α-synuclein expressing rodent models. Background: Parkinson's…Genome-wide bioinformatic analysis of Parkinson’s disease: A focus on neuronal health maintenance
Objective: To scan the human genome for genes involved in neuronal health maintenance in Parkinson's disease (PD). Background: An enormous number of genes and pathways…Comparison of two protocols for neural induction and cultivation of iPSCs derived neural stem cells
Objective: Our objective was to establish and evaluate a protocol for deriving proliferative neural cultures from induced pluripotent stem cells (iPSC). Background: For generating patient…Targeting PDE7 by the small molecule S14: A potential disease-modifying Parkinson�s disease therapy ready to start clinical trials
Objective: The main goal of this work is the regulatory chemical, pharmaceutical and toxicological development of S14, a new therapeutic class for the potential treatment…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.