High Content Screening of synucleinopathy in primary cortical neurons : dissecting out the interplay between the basic synuclein pools
Objective: To set up a robust (see ref 1 for definition) 96-well High Content Screening assay of synucleinopathy in primary cultures of cortical neurons. Background:…Continuous dopaminergic treatment with levodopa/carbidopa intestinal gel in multiple system atrophy: report of three patients
Objective: To evaluate the effect of continuous dopaminergic treatment with levodopa/carbidopa intestinal gel (LCID) on motor and non-motor symptoms in multiple system atrophy (MSA) patients.…Preferred place of death (PPOD) in PD, PSP and MSA
Objective: To ascertain whether people with PD, PSP and MSA have a PPOD Background: Achieving a PPOD is felt to be an important factor in…Is safinamide helpful in multiple system atrophy?
Objective: To retrospectively review the clinical benefit of safinamide in patients with Multiple System Atrophy. Background: Safinamide is a new monoamine oxidase-B inhibitor, with dopaminergic…A First in Human Study of PBT434, a Novel Small Molecule Inhibitor of Alpha-Synuclein Aggregation
Objective: To evaluate the safety, tolerability and pharmacokinetics of PBT434 in healthy volunteers. Background: PBT434 is a novel, small molecule inhibitor of alpha-synuclein aggregation. In…Rapamycin for treating MSA: A preclinical proof of concept study
Objective: To assess the effects of rapamycin on motor behavior, α-synuclein burden and surrogate markers of neurodegeneration in a transgenic mouse model of multiple system…Patient Perspective in Multiple System Atrophy
Objective: To report patient and/ or caregiver perspective in Multiple System Atrophy (MSA). Background: The majority of literature on MSA’s natural history comes from single…Is safinamide useful for atypical Parkinsonian syndromes?
Objective: Seeking new treatment strategies in atypical Parkinsonian syndromes Background: Atypical parkinsonian syndromes (APS) include several entities leading to parkinsonism with atypical features such as…The role of deep brain stimulation targeting GPi in patients with multiple system atrophy
Objective: To report clinical outcomes of two patients diagnosed with MSA-P who underwent bilateral deep brain stimulation (DBS). Background: The role of DBS in patients…PBT434 prevents the accumulation of glial cell inclusions and insoluble alpha-synuclein in a mouse model of Multiple System Atrophy
Objective: To evaluate PBT434 in a transgenic mouse model of multiple system atrophy (MSA) Background: PBT434 is a novel quinazolinone inhibitor of iron-mediated protein accumulation…
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