Tracking longitudinal changes in MSA: TALISMAN study protocol
Objective: The European (EU) TALISMAN study will retrospectively and prospectively explore disease progression and the correlation with plasma neurofilament light chain (p-NfL) and brain MRI…Myelination relevant plasma microRNA biomarkers identified via an innovative data analytic scheme for differential diagnosis of MSA, an Oligodendroglial Synucleinopathy
Objective: To establish an inclusive data analytic scheme to identify and characterize plasma microRNA biomarkers with pathophysiological significance for differentiating the atypical Parkinsonian, Multiple System…Insights from skin biopsies: α-synuclein real-time quaking-induced conversion (RT-QuIC) in patients with Parkinson’s disease and multiple system atrophy
Objective: To characterize skin alpha-synuclein (α-syn) pathology in synucleinopathies as a potential tool for differential diagnosis. Background: Differential diagnosis of PD and MSA represents a…Unraveling the mechanisms of Tubulin Polymerization Promoting Protein TPPP/P25A degradation in oligodendrocytes
Objective: Our aim is to identify the proteolytic pathways responsible for the clearance of TPPP/P25A in oligodendrocytes, which may eventually represent potential therapeutic targets for…Non-invasive imaging markers of iron accumulation in Multiple System Atrophy
Objective: To define the localization and extent of iron accumulation in multiple system atrophy (MSA). Background: Elevated iron concentration in the basal ganglia has been…Laryngeal Electromyography Findings in patients with Multiple System Atrophy
Objective: to systematically evaluate laryngeal electromyography findings, correlate them to laryngeal movement disorders assessed by a systematic task-protocol performed during FEES and clinical laryngeal symptoms.…Mapping regional alpha-synuclein seeding capacity in Multiple System Atrophy
Objective: The objective of our work was to develop a novel high-throughput cell-free assay that allowed us to perform a comprehensive characterization of α-synuclein seeding…Progression of nigro-striatal denervation in cerebellar Multiple System Atrophy: a prospective study
Objective: To study the progression of nigro-striatal denervation and evaluate the capacity for [123I]-FP-CIT-SPECT and parkinsonian signs to differentiate MSA-C from idiopathic late-onset cerebellar ataxia…Fecal Calprotectin in Parkinson’s Disease and Multiple System Atrophy
Objective: To investigate the levels of fecal calprotectin (a marker of intestinal inflammation), in patients with Parkinson's Disease (PD) and multiple system atrophy (MSA) compared…Brain 5-HT1 receptor binding in multiple system atrophy: A [18F]-MPPF PET study
Objective: The primary objective was to compare brain 5-HT1a receptor binding between patients with multiple system atrophy (MSA) and healthy controls (HC). The secondary objectives…
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