Identification of Candidate Cerebrospinal Fluid Biomarkers in Multiple System Atrophy Using Mass Spectrometry‑Based Proteomics in CSF Biobank Samples
Objective: The aim of this study was to identify additional new biomarkers using mass spectrometry-based proteomics in well-defined clinical samples from a phase II clinical…A CSF C Terminal α Synuclein Assay to Differentiate Multiple System Atrophy From Parkinson’s Disease
Objective: Differentiating MSA from PD is clinically challenging. We developed CSF assays to measure full length and major C‑terminally truncated α‑synuclein (αSyn) species for potential…Towards Biomarker-Driven Staging of Multiple System Atrophy Using Longitudinal Neurofilament Light Profiling
Objective: To evaluate neurofilament light chain (NfL) as a longitudinal biomarker of disease burden and progression in Multiple System Atrophy and to explore its potential role…Clinical Significance of Imaging Markers for Cerebellar Ataxia and Parkinsonism in Multiple System Atrophy
Objective: To clarify the interactions among clinical features and imaging markers, and to identify factors contributing to disease severity in MSA. Background: Multiple system atrophy…Fluid Biomarker Signatures in Atypical Parkinsonian Syndromes: Insights into Neurodegeneration and Clinical Heterogeneity
Objective: To evaluate the clinical characteristics and potential biomarkers associated with atypical parkinsonian syndromes. Background: Atypical Parkinson syndromes (APS) are a heterogeneous group of neurodegenerative…Regional α-Synuclein Seeding Activity in Parkinson’s disease and Multiple System Atrophy
Objective: This study aimed to profile regional α‑synuclein (α-syn) seeding activity in postmortem brains from Parkinson’s disease (PD) and multiple system atrophy (MSA) and to…Heart Rate Variability as an Independent Predictive Biomarker for Fall Risk in Multiple System Atrophy
Objective: To evaluate the predictive value of short-term heart rate variability (HRV) parameters in assessing recurrent fall risk among patients with Multiple System Atrophy (MSA).…Central Autonomic Network Alterations in MSA: From Subcortical Degeneration to Prefrontal Reorganization
Objective: To characterize disease- and symptom-specific alterations in the central autonomic network (CAN) in multiple system atrophy (MSA) and associations with autonomic dysfunction. Background: Autonomic…Oligodendrocyte-Specific α-Synuclein Pathology is Linked to Severe Motor Phenotype in a Novel Mouse Model of Multiple System Atrophy
Objective: We characterized the formation of α-synuclein pathology and development of motor phenotypes in a mouse model of multiple system atrophy overexpressing human SNCA in…Altered Glia Limitans Structure and Function in Parkinson’s Disease and Multiple System Atrophy
Objective: To investigate functional alterations of the glia limitans and the consequent changes in glymphatic system dynamics and CD4⁺ T cell infiltration in the disease-affected…
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