Systematic Review of Incidence and Prevalence Studies of Multiple System Atrophy
Objective: This study sought to systematically review the methods and results of previous incidence and prevalence studies of MSA. Background: High-quality incidence and prevalence studies…Next-generation sequencing analysis of circulating microRNAs in multiple system atrophy
Objective: The discriminatory peripheral circulating small non-coding RNAs (sncRNAs) using next-generation sequencing (NGS) between patients of multiple system atrophy (MSA), Parkinson's disease (PD), and healthy controls…The pivotal difference in gut microbiota between multiple system atrophy and Parkinson’s disease
Objective: The knowledge gap between microbiome dysbiosis and pathogenesis of multiple system atrophy (MSA) remains. Background: Mounting evidence has found significant alterations in the gut…Expression profile of circRNA in peripheral blood mononuclear cells of patients with Parkinson’s disease and atypical parkinsonian syndromes
Objective: This study aimed to uncover circRNAs subsets with diagnostic potential for APS and iPD. Background: Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP)…IP-RT-QuIC Identify Disease-Specific Alpha-Synuclein Seeds in serum from patients with syncleinopathy
Objective: To examine whether alpha-synuclein (aSyn) seed exists in the serum and its potential as a serum biomarker. Background: Parkinson’s disease (PD) and Multiple system…LRRK2 G2019S mutation in Multiple System Atrophy, a case report
Objective: Presenting a case of Multiple System Atrophy (MSA) confirmed by skin biopsy with a peculiar genetic profile. Background: MSA is a rare neurodegenerative disorder characterized…An in-vivo study of regional synaptic density loss in patients with Multiple System Atrophy using [11C]UCB-J PET molecular imaging.
Objective: We present preliminary, cross-sectional data, on the in-vivo evaluation of pre-synaptic terminal density in the brain of patients with Multiple System Atrophy (MSA) compared…The study of clonidine growth hormone study amongst definite MSA, PD, PSP, and PAF patients to assess its feasibility as a future non-invasive biomarker
Objective: To analyze the sensitivity and specificity of the clonidine growth hormone (CGH) to distinguish probable multiple system atrophy (MSA) from pure autonomic failure (PAF),…Mosaicism for somatic SNCA copy number variants in multiple system atrophy is related to pathological subtype and presence of α-synuclein inclusions
Objective: To investigate the correlation of somatic copy number variants (CNVs) of the alpha-synuclein gene (SNCA) in multiple system atrophy (MSA) with disease subtype, and…A clinico-genetic study based on the Innsbruck MSA Registry
Objective: To assess family history (FH) for neurodegenerative disorders in people with multiple system atrophy (MSA), compare its prevalence with that of a prospectively recruited…
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