Heterogeneity of multiple system atrophy with an analysis of the clinical case
Objective: Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disease clinically characterized by various combinations of Parkinsonism with resistance to levodopa, cerebellar, autonomic, and…Posterior Fossa Arachnoid Cysts In Two Patients With Suspected Multiple System Atrophy – Cerebellar Type
Objective: To describe two patients with posterior fossa arachnoid cysts later diagnosed with suspected multiple system atrophy – cerebellar type (MSA-C). Background: The diagnosis of…Systematic Review of Incidence and Prevalence Studies of Multiple System Atrophy
Objective: This study sought to systematically review the methods and results of previous incidence and prevalence studies of MSA. Background: High-quality incidence and prevalence studies…Plasma MicroRNA Expression Profiling in patients with Multiple System Atrophy and Parkinson’s Disease
Objective: Our objective was to identify differentially expressed, circulating miRNAs in Multiple System Atrophy-Parkinsonian type (MSA-P) and Parkinson’s disease (PD) which could serve as diagnostic…Altered activity of lysosomal hydrolases in monocyte-derived macrophages as potential biomarker for differential diagnosis of multiple system atrophy
Objective: The aim was to assess the possibility of differentiating synucleinopathies (Parkinson’s disease (PD), dementia with Lewy bodies (DLB), multiple system atrophy (MSA) by lysosomal…Unsupervised Learning Approach for Pathology-Based Subtyping and Staging Multiple System Atrophy
Objective: To develop a classification and staging system for multiple system atrophy (MSA) using data-driven disease progression modeling. Background: MSA exhibits varying degrees of degeneration…Explore cellular heterogeneities of orbitofrontal cortex in multiple system atrophy using spatial transcriptomics
Objective: To explore the spatial organization and cellular complexity of the orbitofrontal cortex (OFC) in multiple system atrophy (MSA) via spatial transcriptomic (SRT). Background: The…Combining alpha-synuclein PET and seeded amplification assays to improve the diagnostic accuracy of Multiple System Atrophy of the Parkinsonian subtype (MSA-P)
Objective: To determine whether the combination of spatial (PET [18F]ACI-12589) and conformational (skin seed amplification assay; SAA) a-syn data aids the early differential diagnosis of…Expression profile of circRNA in peripheral blood mononuclear cells of patients with Parkinson’s disease and atypical parkinsonian syndromes
Objective: This study aimed to uncover circRNAs subsets with diagnostic potential for APS and iPD. Background: Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP)…IP-RT-QuIC Identify Disease-Specific Alpha-Synuclein Seeds in serum from patients with syncleinopathy
Objective: To examine whether alpha-synuclein (aSyn) seed exists in the serum and its potential as a serum biomarker. Background: Parkinson’s disease (PD) and Multiple system…
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