Rethinking Parkinsonism: Limitations in Clinical Diagnosis
Objective: To highlight the limitations in clinically differentiating PD and MSA. Background: The antemortem differentiation of parkinsonian syndromes remains challenging due to overlapping symptomatology, particularly…MicroRNA Landscape of Multiple System Atrophy: Insights from Plasma and Patient-Derived Induced Pluripotent Stem Cell Models
Objective: To identify small non-coding RNAs (sncRNAs) signatures in multiple system atrophy (MSA) and elucidate their functional mechanisms within patient-derived induced pluripotent stem cell-differentiated oligodendrocytes…Proteome-Wide Association Study Identifies Plasma β-Glucuronidase as a Causal Risk Protein for Multiple System Atrophy
Objective: This study aims to identify plasma proteins associated with multiple system atrophy (MSA), using a proteome-wide association study (PWAS) and to determine their causal roles…Atrophy In Multiple System Atrophy Relates To Mitochondrial And Oligodendrocytic Processes
Objective: To investigate the gene expression and neurobiological underpinnings of brain atrophy in MSA using imaging transcriptomics and PET-based molecular annotation Background: The biological mechanisms…A rapidly progressive multiple system atrophy-cerebellar variant model presentingα-synuclein oligomer spreading and phosphorylated α-synuclein aggregate formation accompanied with glial inflammation
Objective: We aimed to develop a rapidly progressive mouse model that recapitulates MSA-C pathology. Background: Multiple system atrophy (MSA) is a severe α-synucleinopathy driven by…LED Light as an Inductor of Optogenetic Activation of Astrocytes in Multiple System Atrophy
Objective: The pathogenesis of Multiple System Atrophy (MSA) involves the spread of misfolded α-synuclein from nerve cells to glia and dysfunction of mitochondria and proteasomes,…Description possible enviromental exposure in AMS Latin America population
Objective: To identify possible risk factors such as environmental exposures in subjects diagnosed with MSA from referral centres in Latin America (Pan-American MSA Study Group)…Atypical Parkinsonism with LRRK2 Mutation Presenting as Multiple System Atrophy
Objective: We describe a rare case of atypical parkinsonism associated with leucine-rich repeat kinase 2 (LRRK2) gene mutation presenting with clinical features suggestive of multiple…Challenges in Diagnosing and Managing Multiple System Atrophy in Low-Resource Settings: Insights from Nepal
Objective: This study aims to explore the diagnostic and therapeutic challenges faced in the management of Multiple System Atrophy (MSA) in low-resource settings, focusing on…Plasma Protein Profiles Reveal Distinct Molecular Signatures in Parkinson’s Disease and Multiple System Atrophy
Objective: We aimed to identify distinct plasma proteins in patients with Parkinson’s disease (PD) and multiple system atrophy (MSA) and evaluate their associations with disease…
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