DaTscan in clinical evaluation of Multiple System Atrophy
Objective: To explore accuracy of DaTscanTM Ioflupane I123 Injection (DaTscan) in a multiple system atrophy (MSA) cohort Background: There are isolated cases of normal DaTscan in neuropathologically confirmed MSA-cerebellar subtype (MSA-C)…Gait characteristics in Atypical Parkinsonism
Objective: We investigated gait characteristics of progressive supranuclear palsy (PSP) and multiple system atrophy (MSA), with the aim to elucidate relatively specific disease differences in…MRI-supported diagnosis of multiple system atrophy: Implications for clinical trials
Objective: To assess whether MSA-specific MRI changes predict a more rapid clinical decline in a cohort of patients with a clinical diagnosis of MSA. Background:…PROSPECT: A UK-based longitudinal observational study of PSP, CBD, MSA and atypical parkinsonism syndromes
Objective: To aid the development of curative treatments, we need to develop better methods for diagnosing Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration (CBD) and Multiple…Oxysterol and chitotriosidase as biomarkers for atypical Parkinsonian symptoms?
Objective: The aim of the study is to establish chitotriosidase and oxysterols as a biomarker for atypical Parkinsonian syndromes in order to make a distinction…Spinal fluid biomarkers for multiple system atrophy – A pilot study
Objective: To evaluate a comprehensive panel of cerebral spinal fluid (CSF) markers in multiple system atrophy (MSA) to define those with potential as future disease…Clinical and polysomnographic features correlates to sleep-disordered breathing in multiple system atrophy
Objective: The purpose of this study is to elucidate whether sleep-discorded breathing (SDB) impact motor and non-motor symptoms in multiple system atrophy (MSA), and to…Esophageal involvement in multiple system atrophy
Objective: To determine the prevalence of esophageal involvement and its impact on clinical manifestations in patients with multiple system atrophy (MSA). Background: Secondary motor disorders…Subjective report does not predict objective swallow impairment in atypical Parkinsonian syndromes
Objective: Swallow and speech disturbances are common in patients with atypical parkinsonism. The emergence of swallowing problems, or dysphagia, is associated with increased morbidity and…Anti-GAD antibody cerebellar ataxia mimicking multiple system atrophy
Objective: To describe a case of anti-glutamic acid decarboxylase antibody (GAD-Abs)-associated cerebellar ataxia (CA), which presented with gradual dysautonomia and parkinsonism fulfilling criteria for MSA,…
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