Preclinical evaluation of sub-anesthetic ketamine infusion to reduce L-DOPA-induced dyskinesias: Is it a ‘chemical’ DBS?
Objective: To evaluate mechanism of long-term activity of sub-anesthetic ketamine infusion to reduce L-DOPA-induced dyskinesias (LID). Background: Ketamine is an anesthetic that, when administered as…The effect of STN-DBS on movement initiation control is modulated by the noradrenergic system: Evidence of an interaction from a combined pharmacological/DBS/EEG study
Objective: Assessing the role of the noradrenergic system underlying the effect of subthalamic nucleus stimulation (STN-DBS) on akinesia. Background: Slowness in movement initiation, associated with…Patient case reports supporting a long-term effect of sub-anesthetic ketamine infusion in reducing L-DOPA-induced dyskinesias
Objective: To evaluate possible long-term anti-dyskinetic activity of low-dose sub-anesthetic ketamine infusion from a retrospective chart review. Background: Repurposing drugs that have already been proven…Modulation of thalamocortical network dynamics via deep brain stimulation in humans with Tourette syndrome
Objective: To (1) investigate the impact on thalamocortical network dynamics in response to low frequency and high frequency deep brain stimulation and (2) uncover the…Improving drug discovery using brain oscillations as biomarkers of Parkinson’s disease
Objective: The aim of this study was to assess the use of cortical oscillations as translational biomarkers for drug development for the motor symptoms of…Structural and functional signature of primary orthostatic tremor
Objective: (1) We aimed to characterize, in primary orthostatic tremor (OT), the structural and functional defects in the cerebellar motor pathways; (2) We correlated the…Cortical grey matter atrophy in the motor system in Friedreich ataxia: The IMAGE-FRDA study
Objective: To examine the anatomical integrity of the motor cortex in Friedreich ataxia (FRDA). Background: FRDA is an inherited neurodegenerative disorder characterised by progressive gait…Early grey matter changes in structural covariance networks in Huntington’s disease
Objective: To identify network integrity changes in Huntington's disease (HD) using grey matter whole brain structural covariance networks and to examine relationships between anatomical networks…Pronounced beta oscillations are a characteristic of the cortico-basal ganglia loop of subacute and chronic animal models of Parkinson´s disease
Objective: To compare the power spectral densities of local field potentials recorded from the cortico-basal ganglia loop of a subacute (reserpine) and a chronic (6-OHDA)…Impaired cerebellum to motor cortex associative plasticity in Parkinson’s disease
Objective: To compare the corticocortical paired associative stimulation (PAS)-induced spike-timing dependent plasticity (STDP)-like plasticity between Parkinson's disease (PD) and healthy elder subjects. Background: Patients with…
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