A mouse model to test the cortical pathogenic theory of Parkinson’s disease
Objective: To develop a mouse model of chronic corticostriatal overactivity and increase expression of corticostriatal alpha-synuclein. Background: Parkinson’s disease typically has a focal motor onset1,…Cortical and cerebellar excitability in essential tremor
Objective: To investigate the functional state of motor cortex excitability and the involvement of the cerebello-thalamo-cortical pathway using transcranial magnetic stimulation (TMS) in patients with…Reducing corticospinal excitability with transcranial static magnetic field stimulation
Objective: To investigate the potential of transcranial static magnetic field stimulation (tSMS) for reducing corticospinal excitability when delivered to the primary motor cortex (M1) or…Home-based transcranial static magnetic field stimulation of the motor cortex for treating levodopa-induced dyskinesias in Parkinson’s disease
Objective: To investigate the potential of transcranial static magnetic field stimulation (tSMS) as a non-pharmacological, non-invasive, home-based treatment to manage levodopa-induced dyskinesias (LIDs) in Parkinson’s…Pallidal deep brain stimulation entrains finely tuned gamma oscillations in motor cortex
Objective: Determine whether therapeutic pallidal deep brain stimulation can entrain finely tuned gamma oscillations in the motor cortex. Background: In Parkinson’s disease (PD), finely tuned…7 Tesla MRI investigation of cortical thickness in patients with Huntington’s disease and age-matched healthy controls
Objective: Evaluate cortical thickness in Huntington's disease (HD) using 7 Tesla (T) MRI. Background: There are currently no effective disease-modifying therapies for HD. In order…Cortical thickness and volume to automatically identify Parkinson’s patients using SVM
Objective: With this work, we aim to automatically classify patients with Parkinson’s disease (PD) and controls, only on the basis of neuroimaging parameters. Background: Dysfunctions…Chronic wireless streaming of pallidal and cortical recordings in Parkinson’s disease over 1000 hours at home
Objective: To investigate pallidal and cortical activity associated with motor signs in Parkinson’s disease (PD), by wireless transmission from an implantable bidirectional interface at home…Driving motor rhythms modulates bradykinesia and cortical excitability in Parkinson’s disease
Objective: To test whether driving beta (β) and gamma (γ) rhythms of the primary motor cortex (M1) by using transcranial alternating current stimulation (tACS) modulates…Maladaptive motor cortex plasticity off medication in Parkinson’s disease patients with levodopa-induced dyskinesias
Objective: To test the hypothesis that motor cortex plasticity is maladaptive in Parkinson's disease (PD) patients suffering from dyskinesias, as compared to non-dyskinetic patients. Background:…
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