Repurposing the MDS-UPDRS part III for early-stage Parkinson’s disease: Supportive evidence for a bradykinesia and rigidity specific sub-score
Objective: Characterize specific motor signs and their impact on the daily life of people with early-stage Parkinson’s disease (PD) before initiation of symptomatic treatment (ST)…Alterations of gait as an early marker of incipient alpha-synucleinopathy
Objective: To investigate early motor signs of α-synucleinopathies in patients with isolated REM sleep behavior disorder (iRBD) using gait analysis. Background: iRBD is an early…WATCH-PD: Longitudinal Digital Assessments in Early Parkinson’s Disease
Objective: To provide a longitudinal profile of early Parkinson’s disease (PD) progression using clinical and digital measures, and to evaluate the extent to which digital…Enhanced sensitivity to bradykinesia progression using digital health technologies in early Parkinson’s disease
Objective: To evaluate the sensitivity of digital biomarkers of bradykinesia to longitudinal progression relative to MDS-UPDRS sub-scores in early-stage Parkinson’s disease (PD). Background: It is…Connectivity Profile for Deep Brain Stimulation in Early-Stage Parkinson’s Disease
Objective: To describe the relationship between stimulation location and motor progression for the deep brain stimulation (DBS) in early-stage Parkinson’s disease (PD) pilot trial cohort…Manifestations of aging and Parkinson’s Disease in low-frequency fluctuations of postural sway velocity
Objective: To distinguish the effects of aging and Parkinson's disease on balance control. Background: Many balance control measures are derived from spontaneous fluctuations of the center…Patient-specific multivariate gray matter volumetric distance to predict disease severity in Parkinson’s disease
Objective: Identifying novel biomarkers to predict disease progression is of paramount importance in patients with Parkinson’s disease (PD). In this study, we utilized Structural Magnetic…P2B001 in the management of untreated PD. Results from a randomized, double-blind, double-dummy controlled trial
Objective: Evaluate the efficacy and safety of P2B001 compared with its components and with Extended-Release pramipexole (ER-PPX, calibration arm) in untreated PD. Background: P2B001 is…Evaluation of an Oral Health Questionnaire in Parkinson’s Disease to Facilitate a Multi-disciplinary Approach to improving Care Through Education
Objective: To determine if the oral health questionnaire (OHQ) devised could help to promote good oral hygiene in Parkinson’s disease (PD) while considering the potential…Impaired Imagery of Tremor in Patients with Essential Tremor
Objective: To investigate neural mechanisms underlying motor imagination (MI) in essential tremor (ET) patients compared to healthy controls using high-density EEG. Background: ET ranges among…
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