A randomized, double-blind, placebo-controlled Phase II Efficacy and Safety Study of the PDE10A inhibitor PF-02545920 in Huntington Disease (AMARYLLIS)
Objective: To assess efficacy on motor function, safety and tolerability of the phosphodiesterase-10A inhibitor PF-02545920 in Huntington disease (HD). Conclusion: PF-02545920 was generally safe and…Costs and outcomes for Parkinson’s disease patients who have their management adjusted by Personal KinetiGraph (PKG)
Objective: To quantify the potential cost savings and quality adjusted life years (QALYs) gained for people with Parkinson’s disease in Australia whose oral therapy was…Naturalistic-based UPDRS-III Minimal Clinically Important Difference (MCID) in early PD
Objective: To find the MCID of the UPDRS-III subscale in early PD subjects, when started on a new dopaminergic drug. Background: The concept of Minimally…Speech in Huntington’s Disease
Objective: To review existing literature on speech function in Huntington’s disease (HD) across the disease spectrum. Background: Impairment in speech production affects the majority of…Feasibility of a multi-sensor data fusion method for assessment of Parkinson’s disease motor symptoms
Objective: To assess the feasibility of measuring Parkinson’s disease (PD) motor symptoms with a multi-sensor data fusion method. More specifically, the aim is to assess…Neuronal correlates of oculomotor alterations in Huntington’s disease. A 18-FDG PET study
Objective: To explore the neuroanatomical correlates of the oculomotor abnormalities in Huntington's disease (HD) through a 18-FDG PET study Background: Alterations of the oculomotor function…Safety and efficacy of high definition tDCS for proprioception and balance in Parkinson’s disease: A pilot randomised trial
Objective: To determine: 1. Is HD-tDCS safe and well-tolerated in PD? 2. Does combined HD-tDCS and physical exercise improve proprioception and balance in PD? Background:…Ankle proprioception and postural instability in Parkinson’s disease
Objective: To determine: 1. Is there a correlation between central and peripheral proprioception in Parkinson’s disease? 2. Does postural instability increase with lack of vision…Evaluation of motor impulsivity in Huntington Disease with a choice reaction time task and brain metabolic (PET 18FDG) imaging
Objective: To describe motor impulsivity in early Huntington disease (HD) with electromyographic (EMG) recordings during a choice reaction time task (Simon Task) and brain metabolic…The impact of a wearable device on Parkinson’s disease motor symptom management in patients starting rotigotine transdermal patch
Objective: Open-label, multi-center pilot study (PD0049) to evaluate the impact of Kinesia 360 (an “at home” wearable device) on motor symptom management in Parkinson’s disease…
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