Drp1 inhibition amelioratesα-synuclein-mediated neurodegeneration in rats
Objective: To provide new insights on the relationships occurring between mitochondria physiology and α-synuclein (α-syn) accumulation in an animal model of progressive neurodegeneration. Background: In…Mitochondrial-nuclear interplay in single respiratory chain-deficient Parkinson’s disease neurons
Objective: To explore the role of the mitochondrial DNA (mtDNA) in the development of respiratory chain complex (CI-IV) deficiencies in the substantia nigra (SN) of…Mitochondrial response precedes intracellular accumulation of α-synuclein in Parkinson’s disease
Objective: To investigate the expression of mitochondrial COX-IV during the progression of Parkinson's disease. Background: Parkinson's disease (PD) is a neurodegenerative disease characterized by the…Mild mitochondrial impairment promotes corticostriatal synaptic plasticity alterations in PINK1 heterozygous knockout mice
Objective: To investigate the effects of the exposure to low-dose rotenone of heterozygous PINK1 knockout (PINK1+/-) mice, compared to their wild-type littermates (PINK1+/+), on dopamine-dependent…Enteric neurons reveal substantial in vivo mitochondrial changes in Parkinson’s disease
Objective: Study in vivo mitochondrial and ganglionic morphometrics of enteric neurons in Parkinson's disease. Background: While well established in autopsy studies, the crucial role of…Evaluation of the role of oxidative stress in Parkinson’s disease and Parkinson plus syndrome
Objective: To evaluate the role of oxidative stress in peripheral blood in patients with Parkinson's disease (PD) and Parkinson plus syndrome (PPS). Background: Slight excess…Increased cerebrospinal fluid lactate levels in Parkison’s disease: Is it a proof of mitochondrial inefficiency?
Objective: The aim of the present study was to investigate the impairment of neuronal energy metabolism, as measured by means of cerebrospinal fluid (CSF) lactate…Beyond initial clinical phenotype of Madelung disease: Myoclonus, gait disorder and multisystem involvement led to genetic diagnosis
Objective: To report the clinical phenotype of an uncommon hereditary systemic disease with slowly progressive gait and movement disorder with genetic identification of two concurrent…Epigenome-wide association study of Parkinson’s disease
Objective: To identify gene-specific DNA methylation associated with Parkinson's disease (PD). Background: There is a growing interest in the role of epigenetic DNA methylation (DNAm)…Fast and simple non-invasive screening tool for mitochondrial changes in Huntington’s disease
Objective: To use Complex I and Complex IV Human Protein Quantity Dipstick Assay Kits to analyse mitochondrial changes in buccal epithelial cells of patients with…
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