Interactions between amyloid-β and microglial activation in Parkinson’s disease
Objective: To evaluate the relationship between microglial activation and amyloid-β deposition in the brain using positron emission tomography (PET) in Parkinson’s disease (PD) with normal…Leukocyte perturbations suggest immune dysregulation in progressive supranuclear palsy
Objective: Compare the serum cytokine profiles and phenotypes of peripheral blood mononuclear cells (PBMCs) in a patient with Progressive Supranuclear Palsy (PSP) with his healthy…Glatiramir acetate (Copaxone) causes restoration of the striatal dopamine in a progressive MPTP mouse model of Parkinson’s disease
Objective: To assess if a microglial modulator, Glatiramer Acetate (GA), can restore loss of striatal dopamine (DA) and behavioral deficits following progressive 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP)…Effect of intra-striatal 6-OHDA lesion on extra-striatal structures in the mouse
Objective: Characterization of extra-striatal manifestations in the 6-hydroxydopamine (6-OHDA) Parkinson's disease (PD) animal model. Background: PD is a neurodegenerative disorder characterized by progressive loss of…Modulation of microglia function in the prion-like spreading of α-synuclein in the murine brain
Objective: We aimed to analyze the influence of two microglia-related pathways on the accumulation of α-synuclein aggregates and neurodegeneration after intracerebral injection of sonicated murine…Neurodegeneration and microgliosis are independent of α-synuclein aggregation in a mouse model of "prion-like" α-synuclein speading
Objective: Our aim was to test if α-synclein aggregation drives neuronal demise and microglial activation in a murine model of induced-α-synucleinopathy. Background: Pathological α-synuclein aggregates…Role of macroautophagy in regulating microglia-mediated neuroinflammation and dopaminergic neuron injury
Objective: To investigate the potential role of macroautophagy in the regulation of microglia-mediated neuroinflammation and dopamine neuron injury. Background: Chronic neuroinflammation, a process mediated by…Piper longum L. alkaloids inhibit lipopolysaccharide-stimulated microglial activation and protect nigral dopaminergic neurons
Objective: The ethanol-extracted alkaloids from the dry seeds of Piper longum L. (PLL) (family Piperaceae) PLA contain numerous compounds. We evaluate the potential of PLA…Lrrk2 alleles modify host response to microbial infections
Objective: The mechanisms by which allelic changes in LRRK2 modulate the susceptibility to Parkinson's disease, Crohn's disease and leprosy remain unknown. We hypothesized that leucine-rich…The role of neuroinflammation in the development of Parkinson’s disease dementia
Objective: To evaluate, at post-mortem, the pattern and characteristics of neuroinflammatory change in Parkinson's disease (PD) brain and to assess its relationship with aberrant alpha-synuclein,…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.