The Inhibition of Mitochondrial NLRP3 Inflammasome Decreases Dopaminergic Cell Death in a 6-OHDA Mouse Model of Parkinson’s Disease.
Objective: To evaluate the possible neuroprotective effects of mitochondrial NLRP3 inflammasome inhibition in a 6-hydroxydopamine mouse model of Parkinson's Disease. Background: Overactivation of brain immune…Quercetin hinders Glial Activation to Alleviate the Cadmium Induced Dopaminergic Alteration via TNFα mediated CAMKIIα/ERK activation
Objective: The present study has therefore been carried out identify neuroprotective role of quercetin in alleviating the cadmium induced dopaminergic dysfunctions via glial mediated deactivation…miR-218-5p Regulates Microglia-mediated Neuroinflammation through Type I Interferon Response in Parkinson’s Disease
Objective: To explore the effect of miR-218-5p on microglia activation and dopaminergic neurons damage in mice model of Parkinson's disease(PD) and its potential mechanisms. Background:…Brain glia activation and peripheral inflammation in Parkinson’s disease: a PET study
Objective: Abnormal activation of immune system is an important pathogenesis of Parkinson's disease, but the relationship between peripheral inflammation, central glia activation and dopaminergic degeneration…Neurodegeneration and neuroinflammation for biomarker development in MSA
Objective: To investigate the diagnostic and prognostic value of fluid-based and PET imaging biomarkers related to neurodegeneration and neuroinflammation in Multiple System Atrophy (MSA). Background:…The association of CSF sTREM2 with cognitive decline and its dynamic change in Parkinson’s disease: Analysis of the PPMI Cohort
Objective: This study aims to investigate the baseline and longitudinal changes of soluble fragments of triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal…Modeling Cerebellar Limb Dysmetria and Impaired Spatial Memory in Rats Using Lamivudine: A preliminary study
Objective: This study is aimed at determining if any constituent of combination antiretroviral therapy (cART) can induce cerebellar limb dysmetria and spatial memory impairments in…A longitudinal PET study to assess the state of microglia activation in a Phase 2 study of Laquinimod as a treatment for Huntington’s disease (LEGATO-HD)
Objective: To assess in vivo in Huntington’s disease (HD) changes in microglia activation state, due to treatment with laquinimod, as reflected by changes in 11C-PBR28…hUC-MSCs ameliorated CUMS-induced depression by modulating complement C3 signaling-mediated microglial polarization during astrocyte-microglia crosstalk
Objective: To demonstrate whether hUC-MSCs can benefit depressive-like behavior by altering C3/C3a-C3aR signaling to impact microglia polarization in the CUMS model. Background: Major depressive disorder (MDD) has been…A study of gut microbiota dynamics in Parkinsonian mice
Objective: To examine gut microbiota in the M83 mouse model of PD. Background: Parkinson’s disease (PD) is a chronic neurodegenerative disease characterized by motor and…
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