mGlu3 receptors in Parkinson’s disease as a candidate target for neuroprotective therapy: evidence from preclinical studies to human genetic.
Objective: In a toxicological model of mouse parkinsonism through chronic injection of MPTP, we examined whether the presence or absence of mGlu3 receptors affected neurodegeneration…Changes in the level of glial neurotrophic factor in Parkinson’s disease depending on the form
Objective: To study the level of glial neurotrophic disease in blood plasma in patients with Parkinson's disease (PD) depending on the form Background: Neurotrophic factors…Investigating inflammatory mechanisms in iPSC-derived LRRK2 microglia
Objective: To characterize microglial function and inflammatory mechanisms in LRRK2-associated Parkinson’s disease (PD). Background: PD is a neurodegenerative disease affecting primarily dopaminergic neurons of the…Effects of exosomes devised from dopaminergic neurons overexpressing α-synuclein on autophagy and inflammation in microglia
Objective: The aim of this study was to investigate whether the exosomes secreted by dopaminergic neurons over-expressing α-synuclein could regulate the inflammation of microglia via…Activated microglia contribute to MPTP-induced impairment of cardiovascular function
Objective: To investigate the contribution of microglia in MPTP-induced loss of adrenergic neurons and impairment of cardiovascular function. Background: Parkinson’s disease (PD) is a neurodegenerative…The interaction between iron metabolism and inflammation in Parkinson´s disease: an in vivo and post mortem study
Objective: To assess the relationship iron and inflammatory markers in an in vivo and post mortem study of Parkinson´s disease subjects. Background: Although neuroinflammation and…Microglia as modulators of exosomal alpha-synuclein transmission
Objective: It is highly desirable to make clear the underlying mechanism of exosomes-involved communication in the synucleinopathy pathogenesis. Background: Emerging evidence suggests that exogenous pathogenic…Nurr1 gene: A new research target for Parkinson’s disease
Objective: The objective of our study is to determine if Nurr1 gene, a transcription factor essential for dopamine (DA) neuron development and survival, is a…Role of microglia in the transmission of α-syn-containing exosomes
Objective: we investigated the role of microglia in the transmission of α-syn-containing exosomes and offer a new insight into the mechanism of PD pathogenesis. Background:…Partial depletion of peripheral M1 macrophages ameliorates the neuroinflammation and dopaminergic neuronal death in the brain of a MPTP-induced mouse model of PD
Objective: Neuroinflammation in the PD brain involves the activation of microglia and the increasing levels of inflammatory cytokines. Several studies have shown that the peripheral…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.