Focus on the Locus: Ultra-high field MRI evaluation of locus coeruleus structure and function in Parkinson’s Disease
Objective: To develop an imaging protocol for 7 tesla magnetic resonance imaging (MRI) that captures the structural and functional consequences of locus coeruleus (LC) neurodegeneration.…Regional subcortical volumes predict gait decline in early Parkinson’s disease
Objective: To predict changes in discrete gait characteristics in early Parkinson’s disease (PD) compared to healthy ageing, using subcortical brain volumes quantified in early disease.…Open-label safety and tolerability of L-Dihydroxyphenylserine (L-DOPS) and high dose carbidopa therapy in Parkinson’s disease patients
Objective: To assess safety, tolerability, and central effects of L-Dihydroxyphenylserine (L-DOPS), in Parkinson’s disease (PD) patients treated with DOPA decarboxylase inhibition. Background: Norepinephrine (NE) is…Speculation on the timing of iron deposition in the putamen of patients with multiple system atrophy: multimodal MRI study
Objective: We sought to investigate the temporal pattern of iron deposition in the putamen of patients with multiple system atrophy (MSA) by calculating conditional probabilities…Different patterns of cortical and subcortical perfusion changes in essential tremor and tremor-dominant Parkinson’s disease using voxel-based analysis of 3D arterial spin-labeling imaging
Objective: We aimed to evaluate cerebral blood flow (CBF) in patients with untreated ET, de novo tremor-dominant PD (PDT) and age- and gender- matched controls…Structural changes in non-manifesting GBA mutation carriers and GBA mutation carriers with Parkinson’s disease
Objective: We aimed to investigate whether GBA mutations are associated with structural abnormalities in a cohort of GBA mutation carriers with and without manifested PD.…Impaired cerebral vasoreactivity in patients with Parkinson’s disease: clinical and imaging correlates
Objective: To determine the clinical and imaging correlates of impaired cerebral autoregulation as measured with cerebral vasoreactivity (CVR) in patients with idiopathic Parkinson’s disease (PD).…Investigation of 531 cases of neuromelanin sensitive imaging, about its characteristics by disease
Objective: To investigate the utility of Neuro-Melanin sensitive MRI (NMI) by 3T MRI for diagnosis, the relationship and severity in Parkinson's disease (PD) and related…The neural representations of the voice tremor spectrum
Objective: Investigate shared and disorder-specific brain abnormalities in essential and dystonic tremor of voice using functional and structural brain imaging. Background: Essential tremor of voice…Brain MRI-based discrimination between multiple system atrophy type cerebellar from other late onset sporadic cerebellar ataxias: a prospective study with implications for diagnosis criteria
Objective: To evaluate, in patients with sporadic late-onset cerebellar ataxia (SLOCA), the discriminative value of each of the magnetic resonance imaging (MRI) features for the…
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