Evolving inclusion criteria in early manifest Huntington’s disease (HD) to address striatal atrophy: Lessons from HD-GeneTRX-1, the first gene therapy trial
Objective: To describe the early screening experience and evidence-based adaptations to the inclusion criteria for HD-GeneTRX-1 (NCT04120493). Background: AMT-130 is an AAV5-based gene therapy intended…EVALUATION OF THE ABSENCE OF NIGROSOME 1 BY MAGNETIC RESONANCE 3 TESLA IN PARKINSON’S DISEASE ACCORDING TO TIME OF EVOLUTION TO DIAGNOSIS VS MESENCEPHALIC ECOGRAPHY.
Objective: The primary objective was to evaluate the absence of nigrosome 1 in 3TMRI in a group of patients with PD according to their evolutionary…Cognition-related functional topographies in Parkinson’s disease: Localized loss of the ventral default mode network
Objective: We sought to determine whether functional network abnormalities seen in patients with Parkinson’s disease (PD) and cognitive decline reflect the loss of the default…Expanding the phenotypic spectrum of diabetic striatopathy: a case series
Objective: To illustrate the spectrum of diabetic striatopathy by presenting 3 cases with different clinical and neuroimaging findings. Background: Diabetic striatopathy is a rare complication…Validation of smartphone-based active tests with structural neuroimaging in Huntington’s disease
Objective: Explore the association of smartphone-based active tests in the Roche Huntington’s disease (HD) Digital Monitoring Platform (dMP) with brain imaging. Background: Remote digital monitoring…Cerebral white matter atrophy may be associated with the performance of activities of daily livings in patients with Parkinson’s disease
Objective: To assess whether global or regional brain structural abnormalities are associated performance of activities of daily livings (ADL) in patients with Parkinson's disease (PD).…Motor symptom lateralization influences cortico-striatal functional connectivity in Parkinson’s disease
Objective: To evaluate the effect of lateralization on various cortico-striatal circuits through resting state functional MRI. Background: Striatum is unevenly impaired bilaterally in Parkinson’s disease.…Pyramidal pathway changes at conventional brain 3T-MRI in patients with hereditary spastic paraplegia
Objective: Our aim was to evaluate the occurrence of motor cortex (MC) and cortico-spinal tract (CST) magnetic resonance imaging abnormalities in patients with hereditary spastic…Comparison of correlations of structural magnetic resonance imaging measures with smartphone-based active tests and clinical tests in Huntington’s disease
Objective: The current study aims to explore the similarities and differences between neuronal correlates of established clinical or novel Roche Huntington’s disease (HD) Digital Monitoring…A direct longitudinal comparison of free water diffusion MRI and DaTscan SPECT in Parkinson’s Disease.
Objective: To compare the within-subject longitudinal sensitivity of PD biomarkers derived from DaTscan and Diffusion MRI. Background: Parkinson’s Disease (PD) is associated with impaired striatal…
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