Reconstruction of the dentato-rubro-thalamic tract based on the anatomy of the rubral wing
Objective: We investigated reconstructing the entire dentato-rubro-thalamic tract (DRT) by an anatomical “rubral wing”-based tractography and compare its correlation with clinical outcomes to those of…Structural analysis of the basal ganglia using ex vivo 7T MRI can differentiate frontotemporal lobar degeneration with TDP-43 vs tau accumulation.
Objective: Ex vivo 7T MRI can identify macrostructural changes in the basal ganglia that reflect underlying neuropathology, and can be used to differentiate between proteinopathies…Free water imaging of the cholinergic forebrain in body vs. brain-first Parkinson’s disease subtypes
Objective: To investigate the relationship between basal forebrain (BF) neurodegeneration and cholinergic system in body vs brain-first Parkinson’s disease (PD) subtypes. Background: Free water imaging…Examining the association between adverse effects of magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy for essential tremor and structural connectivity using probabilistic tractography targets
Objective: We examine the relationship between adverse effects of MRgFUS thalamotomy in essential tremor (ET) patients and the structural connectivity of the ventral intermediate nucleus…Longitudinal free-water changes in dementia with Lewy bodies
Objective: To characterize longitudinal diffusion microstructural changes in individuals with dementia with Lewy bodies (DLB). Background: Diffusion-weighted MRI (dMRI) examines tissue microstructure integrity in vivo.…An investigation of early changes in the brain due to mild cognitive impairment in Parkinson’s disease
Objective: To identify baseline structural brain differences between individuals with Parkinson's disease (PD) who go on to develop mild cognitive impairment (PD-MCI) and those who…Radiological markers of CSF α-synuclein aggregation in Parkinson’s disease patients
Objective: To investigate the association between cerebrospinal (CSF) αS aggregates, MRI, and dopamine transporter spectral tomography (DaTscanTM) imaging metrics. Background: Synuclein amplification assays (SAA) enables…An in-vivo study of the integrity of the nigrostriatal pathways in drug-naive Parkinson’s disease patients using [11C]PE2I PET and neuromelanin-Magnetic Resonance Imaging
Objective: This study evaluated the relationship between the neurodegeneration of the substantia nigra neurons, assessed using Neuromelanin-sensitive MRI, and of the loss of striatal dopaminergic…Diabetic striatopathy presenting without hyperkinetic movements
Objective: To demonstrate a case of Diabetic striatopathy presenting without hyperkinetic movements Background: Diabetic striatopathy is an uncommon neurological complication associated with poorly controlled Diabetes Mellitus…Does hyposmia induce apathy in early Parkinson’s disease? Lessons from structural brain connectivity
Objective: To study changes in microstructural integrity of white matter tracts associated with apathy in patients with early Parkinson’s disease (PD) and hyposmia Background: Smells…
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