Contribution of blood lipid profile to long-term outcome in idiopathic normal pressure hydrocephalus
Objective: Here, we outlined the blood lipid profile, including derived indices of metabolic dyshomeostasis, in iNPH patients, and investigated relationships with brain MRI-based pathology markers,…Metabolomic profile as a biomarker of non-motor symptoms severity in patients with Parkinson’s disease
Objective: To investigate possible associations between serum metabolomic profiles and non-motor symptoms (NMS) frequency and intensity in PD patients Background: Metabolomic studies are providing growing…Biofluid Markers in Parkinson’s Patients and Correlation with Cognitive Profile
Objective: The purpose of this study was to determine potential biofluid biomarkers for cognitive impairment in a cohort of Parkinson's disease (PD) patients. Here we…Lipid Alterations in Central Nervous System and Plasma During Early Stages of Parkinson’s Disease
Objective: To identify early lipid alterations in a progressive mouse model of Parkinson’s disease (PD) and to determine whether peripheral lipid signatures reflect lipid changes…Parkinsonism Revealing a Late Form of Niemann-Pick Disease About a Case
Objective: Niemann-Pick type B (NPB) is a rare, autosomal dominant hereditary disorder. Clinical presentation is primarily visceral. Neurological manifestations are rare, unlike in other types…Using Zebrafish Model to Investigate Complex Hereditary Spastic Paraplegia Caused by EPT1 Variants
Objective: To generate disease-representative zebrafish models using CRISPR-Cas9 technique.To characterise the zebrafish models by performing phenotypic characterization, neurobiological experiments, lipidomic and RNASeq studies.To test targeted…Efficacy of adhering to a Ketogenic Diet in Parkinson’s Disease: a Systematic Review and Meta-Analysis
Objective: We aimed to analyse the efficacy of Ketogenic Diet (KD) in metabolic and motor characteristics of patients with Parkinson's Disease (PD). Background: Many studies…Cerebrospinal fluid measured α-synuclein is related to metabolite profile in the serum and CSF
Objective: Determine metabolites associated with cerebrospinal fluid (CSF) measured α-synuclein (α-syn) using untargeted metabolomics measured in the serum and CSF. Background: Several large studies have…The Impact of Statin Therapy on Motor and Non-Motor Symptoms in Parkinson’s Disease: A Meta-Analysis
Objective: To assess the effects of statin therapy on motor and non-motor symptoms in Parkinson’s disease (PD) through a meta-analysis of randomized controlled trials. Background:…The sphingolipid Lyso-Gb3, a biomarker for the lysosomal storage disorder Fabry Disease, is significantly elevated in blood from patients with Parkinson’s Disease
Objective: To better understand lysosomal dysfunction in Parkinson’s Disease. Background: Lysosomal dysfunction and α-synuclein accumulation play central roles in Parkinson’s Disease. They are interconnected by…
- « Previous Page
- 1
- 2
- 3
- 4
- …
- 10
- Next Page »