Sex specific role of dyslipidemia and statin use in Parkinson’s disease pathogenesis
Objective: Our aim was to characterize the role of dyslipidemia and statin use in Parkinson’s disease (PD) development, specifically with respect to differences in significance…Fatty Acid Metabolic Reprogramming Regulates Glial-Epithelial Axis via Nur77 Palmitoylation in Intestinal Dysfunction in Parkinson’s Disease
Objective: This study aims to elucidate the regulatory role of stearoyl-CoA desaturase 1 (SCD1) in Parkinson’s disease (PD)-associated intestinal dysfunction, focusing on its mechanism in…Genetic Correlations Between Parkinson’s Disease and Circulating Metabolites
Objective: To use genome-wide association studies (GWASs) to identify genetic correlations between Parkinson’s disease (PD) and circulating metabolites. Background: Metabolomics is the study of small…Rare Variant Analysis of Sphingolipid-related Genes in Large Chinese Parkinson’ s Disease Cohorts
Objective: This study investigated the link between rare variants in sphingolipid-related genes and Parkinson’s disease (PD) in a Chinese mainland population. Background: Recently, growing evidence…Association of high-density lipoprotein cholesterol and related inflammatory index with neurodegeneration in drug-naïve dementia with Lewy bodies
Objective: We aimed to clarify the association of serum cholesterol levels and related inflammatory index with the degeneration of nigrostriatal dopaminergic neurons and clinical symptoms…Oligodendrocyte-specific mRNA therapy with lipid nanoparticles
Objective: To develop lipid nanoparticles with high efficiency and specificity to introduce mRNA into oligodendrocytes. To denmonstrate the potential therapy of Krabbe disease as one…Association between environmental phthalates exposure and gut microbiota and metabolome in dementia with Lewy bodies
Objective: We examined the association between environmental phthalates (PAEs) exposure and gut microbiota and metabolome in dementia with Lewy bodies (DLB). Background: Alongside genetic factors,…Interim Analysis of the Feasibility of Mediterranean-Ketogenic Dietary Interventions in Parkinson’s Disease
Objective: To assess the feasibility of combining Mediterranean and ketogenic dietary principles in persons with Parkinson’s disease (PwP). Background: Dietary interventions have been proposed as…Inter- and intra-day variability in β-Glucocerebrosidase activity and pathway biomarkers in healthy volunteers and patients with Parkinson’s disease with a GBA1 mutation
Objective: Characterize inter- and intra-day variability of β-glucocerebrosidase (GCase) activity, using a live-cell assay, and glucosyl-β sphingosine levels in healthy volunteers (HVs) and Parkinson’s disease…AAV-mediated gene therapy for GBA-PD
Objective: Development of a gene therapy-based drug for treatment of GBA-PD, a genetic subtype of Parkinson’s disease Background: Mutations in GBA1, the gene encoding glucocerebrosidase…
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