Identification and Characterization of Selective and High Affinity Small Molecules as Positron Emission Tomography (PET) Imaging Tracers for Pathological Alpha-Synuclein
Objective: The aim is to develop small molecular weight compounds which bind selectively and with high affinity to alpha-synuclein (a-syn) aggregates as diagnostic PET imaging…Submandibular gland is a suitable tissue for alpha synuclein pathology in Parkinson’s disease
Objective: To validate the role of α-synuclein (AS) pathology in submandibular gland (SMG) as a biomarker for Parkinson disease (PD). Background: The pathologic hallmark of…Are Lewy bodies associated with sympathetic pathology in dementia subjects?
Objective: Determine if Alzheimer disease (AD) subjects with Lewy bodies show sympathetic cardiac denervation. Background: Comorbid Lewy body (LB) pathology is very common in AD,…LRRK2 p.Leu119Pro and p.Leu488Pro in a family with neuropathologycally confirmed Parkinson´s disease without Lewy bodies
Objective: To describe the clinical features, genetic analysis and brain pathology of some members of a family affected by Parkinson´s disease. Background: Mutations of the…Parkinson’s disease anxiety is associated with Lewy bodies in the Anterior Cingulate
Objective: The goal of this study is to determine if there is an association between anxiety and the presence and regional distribution of Lewy bodies…Papez circuit atrophy in Dementia with Lewy Bodies
Objective: In this ex-vivo study, we aimed to assess atrophy in regions and subregions of the Papez Circuit, a network important for memory function, in…Characterization of color vision impairment in Lewy Body Diseases
Objective: We sought to characterize the prevalence of color vision impairment in DLB patients and investigate how color vision impairment in DLB patients was associated…Lewy body disease with visual hallucination: Optic radiation abnormalities on phase difference-enhanced imaging (PADRE)
Objective: We assessed structural abnormalities of optic radiation (OR) in healthy subjects (HS) and dementia with lewy body (DLB) patients (with visual hallucination) (VH) on…Prevalence and influence of co-pathologies in patients with autopsy-confirmed Lewy body disorders: A systematic review
Objective: To determine the prevalence of selected co-pathologies in patients with Lewy Body disorders, as well as their influence on disease expression. Background: The presence…Targeting alpha-Synuclein Aggregation for the Treatment of Parkinson’s Disease
Objective: To develop small molecular weight compounds (SMEs) as disease-modifying agents, which are designed to arrest or even reverse the aggregation process of alpha-synuclein (aSyn)…
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