Longitudinal evolution of impulsive-compulsive behaviors and their prognostic value in Parkinson’s disease
Objective: To characterize longitudinal trajectories of impulsive-compulsive behaviors (ICD) in PD and to determine their prognostic value for quality of life and dopaminergic medication requirements…Safer AI Dosing Recommendations in Parkinson’s Disease Through Uncertainty-Adaptive Prediction
Objective: To develop and validate a uncertainty-adaptive AI framework to improve the safety and clinical utility of levodopa dose predictions by explicitly flagging high-risk, ambiguous cases…Differences in Levodopa Equivalent Daily Dose (LEDD) Based on Disease Duration in Parkinson’s Disease Patients at RSCM – A Tertiary National Referral Hospital
Objective: This study aimed to evaluate differences in LEDD among Parkinson's disease (PD) patients based on disease duration categories from onset at RSCM Neurology Outpatient…Treatment Patterns in Parkinson’s Disease in Kyrgyzstan: Evidence from a Kyrgyz PD Cohort
Objective: To characterize treatment patterns and access to antiparkinsonian medications among patients with Parkinson’s disease (PD) in Kyrgyzstan. Background: Access to treatment for PD remains…Electronic Health Record Integration Improves Markerless 3D Gait-Based Prediction of Parkinson’s Disease Motor Symptom Severity
Objective: To evaluate if integrating electronic health record (EHR) data with markerless 3D gait kinematics improves prediction of Parkinson's disease (PD) motor symptom severity. Background:…Levodopa dosing regimen influences repetitive tongue force maintenance in Parkinson’s disease
Objective: To investigate whether levodopa (LD) dosing regimen influences the dynamics of repetitive maximal tongue pressure (MTP) in patients with Parkinson’s disease (PD). Background: Reduced…Levodopa-Induced Dyskinesia Predicts Falls, Fall-Related Injuries, and Their Consequences in Parkinson’s Disease: A Prospective PPMI Cohort Study
Objective: This study aimed to (i) assess the prevalence and incidence of falls, (ii) identify contributors to falls, and (iii) examine injuries and consequences caused…Probiotic Y7 Intervention Is Associated with Improved Motor, Gut-Related, and L-DOPA-Related Outcomes in a Rat Model of Parkinson’s Disease
Objective: To evaluate whether probiotic Y7 intervention improves disease-related outcomes and influences L-DOPA-related responses in a 6-hydroxydopamine (6-OHDA) rat model of Parkinson’s disease (PD). Background:…Nutritional Status as a Modifiable Determinant of Clinical Outcomes in Parkinson’s Disease: A 12-Month Longitudinal Study in Patients Treated with DBS and L-Dopa
Objective: To analyze longitudinal changes in nutritional status in Parkinson’s disease (PD) patients treated with deep brain stimulation (DBS), compared with pharmacological therapy (L-dopa) and to…Corticobasal Degeneration With Alien Limb Phenomenon and Severe Cognitive Decline: A Levodopa-Resistant Clinical Case
Objective: To describe a clinical case of corticobasal degeneration presenting with alien limb phenomenon, severe cognitive decline, and resistance to high-dose levodopa therapy. Background: Corticobasal…
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