Chronic levodopa treatment accelerates the disorders of circadian rhythm in 6-OHDA induced Parkinson’s disease model
Objective: We aimed to study the effect of levodopa on circadian rhythms in 6-OHDA lesioned rats, and to clarify whether the disturbance of the circadian…Long-duration response to levodopa in Parkinson’s disease is independent of disease duration: A prospective study on de novo patients in Ghana
Objective: To prospectively investigate the response to acute levodopa challenge in patients with advanced Parkinson's disease (PD) never treated before. Background: Pathophysiological mechanisms underlying motor…Phenotypic spectrum and longitudinal outcome of Parkinson’s disease patients with psychosis
Objective: We studied the phenotypic characteristics of psychosis in PD patients, their associated risk factors and assessed their long term outcome. Background: Psychosis in PD…Levodopa/carbidopa intestinal gel, neuropathy, and B-vitamins – Is there an association?
Objective: To assess the frequency of neuropathy and its neurophysiological characteristics in orally and levodopa/carbidopa intestinal gel (LCIG) treated patients with advanced idiopathic Parkinson´s disease…Motor phenotype classification in moderate to advanced PD: Data from the BioFIND study
Objective: To evaluate the validity of motor phenotype classification in response to dopaminergic agents in moderate to advanced Parkinson's disease (PD) patients enrolled in the…Efficiency of carotid endarterectomy in vascular parkinsonism in patients with stenotic carotid artery disease
Objective: Primary aim of investigation was to evaluate the effectiveness of carotid endarterectomy (CEA) in patients with vascular parkinsonism (VP) with stenotic lesions of carotid…The influences of STN-DBS and levodopa on cardiovascular autonomic function in patients with Parkinson’s disease: Evaluated by trigonometric regressive spectral analysis
Objective: To explore the effects of STN-DBS and levodopa on cardiovascular autonomic function in PD. Background: Cardiovascular autonomic dysfunction has been shown in patients with…Changes in serum amino acid levels with progression of Parkinson’s disease
Objective: The purpose of this study was to analyze changes in serum amino acid profile with progression of Parkinson's disease (PD). Background: PD is a…The relationship between impulse control disorders and dyskinesia in Parkinson´s disease: The ALTHEA study
Objective: To report (1) the relationship between the occurrence of impulse control disorders (ICDs) and dyskinesias, and (2) the correlations between specific ICDs and the…Minimizing levodopa titration period for Parkinson’s disease (PD)
Objective: Develop an optimization algorithm that individualizes the pharmacokinetics-pharmacodynamics (PKPD) infusion models of levodopa, to improve the efficacy of dose titration and reduce the number…
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