Utility of Acute Levodopa Challenge Test In Early Parkinsonism
Objective: This prospective cohort study was conducted to evaluate the sensitivity and specificity of different outcomes of acute levodopa challenge test(ALCT) (motor improvement, development of…Motor and non-motor symptoms of a 7.5-year prospective study of patients with Parkinson’s disease
Objective: Previously, we retrospectively reported the prevalence and risks of motor and non-motor symptoms of a large number of patients (1453) with Parkinson’s disease (PD)…Efficacy of ND0612 for nocturnal problems and early morning OFF
Objective: ND012 is a drug-device combination delivering liquid L-dopa/carbidopa (LD/CD) via continuous SC infusion. This secondary analysis evaluated the efficacy of 2 dosing regimens (R1:…Design of a Phase 3 Efficacy and Safety Trial of Accordion Pill™ Carbidopa/Levodopa for Parkinson’s Disease (PD) Patients Experiencing Motor Fluctuations
Objective: To review the design and unique features of an ongoing phase 3 trial of a gastric-retentive formulation of carbidopa/levodopa (CD/LD), the Accordion Pill™ (AP),…Bdnf rs6265 and Other Variants Predict the Efficacy of Levodopa Monotherapy in Early-Stage Parkinson’s Disease
Objective: To determine whether relatively prevalent variants in the gene for brain-derived neurotrophic factor (Bdnf) are associated with differential efficacy of levodopa or other dopaminergic…Using saccades as an early test of levodopa treatment in Parkinson’s Disease
Objective: It is important to know what potential confounding effects the medications used to treat Parkinson’s disease (PD) have on eye movement, in order to…Efficacy of liquid sinemet on non-motor symptoms in Parkinson’s disease
Objective: To investigate the short term effect of liquid sinemet on the non-motor symptoms of people with advanced Parkinson’ disease (PD) who experience complex motor…Variation in the L-dopa motor response in pathologically confirmed Parkinson’s disease
Objective: To examine the L-dopa-response (improvement in motor symptoms) in published cases of pathologically confirmed Parkinson’s disease (PD). Background: L-dopa responsiveness supports the diagnosis of…Levodopa Effect on Dual-Tasking in Freezing of Gait in Parkinson’s Disease
Objective: To assess the effect of levodopa on dual-tasking in situations triggering freezing of gait (FOG) in Parkinson’s disease (PD). Background: The frequency and severity…Highly-selective blockade of 5-HT2A receptors with EMD-281,014 reduces the severity of L-DOPA-induced psychosis and dyskinesia in the MPTP-lesioned marmoset model of Parkinson’s disease
Objective: To investigate the effect of the highly-selective serotonin 2A (5-HT2A) receptor EMD-281,014 on L-3,4-dihydroxyphenylalanine (L-DOPA)-induced psychosis-like behaviours (PLBs) and dyskinesia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned…
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