Motor- and Non-motor Symptoms in Patients Treated with 24-hour Daily Levodopa-Carbidopa Intestinal Gel Infusion: Analysis of the COSMOS Observational Study
Objective: Describe and compare demographic and clinical characteristics, motor, and non-motor symptoms for patients with advanced Parkinson’s disease (APD) by daily duration (<24 hours or…Altered interhemispheric synchrony in Parkinson’s disease patients with levodopa-induced dyskinesias
Objective: Our investigation aimed to explore interhemispheric functional alterations and its corresponding morphological synchronization changes. Background: Levodopa-induced dyskinesias are common motor complication of Parkinson’s disease…Rapid on-time onset and sustained improvements in motor states throughout the day following treatment with levodopa/carbidopa intestinal gel (LCIG) vs immediate-release levodopa/carbidopa oral capsules (LCIR)
Objective: To assess the speed of on-time onset and characterize the patterns of motor states throughout the day in advanced Parkinson’s disease patients treated with…Gut Microbiote Distinctive Features and Microbiota-Metabolome Profile in Parkinson’s Disease: Focus on Levodopa and LCIG
Objective: The aim of this work was to study the microbiome of PD patients, studying the effect of dopaminergic drugs mainly focusing on the effect…Levodopa Challenge Test for Prediction of Deep Brain Stimulation Efficacy on Motor Functions for Parkinson’s Disease
Objective: To investigate the correlation between pre-operative response to levodopa following levodopa challenge test and the efficacy of deep brain stimulation (DBS) on motor functions…Levodopa improves tremor symptom by reducing the connectivity between the thalamic subregions and postcentral gyrus in patients with Parkinson’s disease
Objective: To explore the mechanism by which levodopa modulates the functional connectivity of the subregions of the thalamus and which subregional connectivity changes are associated…Researches on the correlation between wearable device data and UPDRS scores in patients with Parkinson’s disease
Objective: To collect spatiotemporal parameter information of motor symptoms in patients with Parkinson's disease (PD) using wearable device, and analyze its correlation with the Unified…Pharmacokinetics of Levodopa in patients with Parkinson’s disease: Efforts toward a predictive model
Objective: Our aim was to explore correlations between the pharmacokinetics of levodopa (LD) and clinical manifestation in patients with Parkinson’s disease (PD). Our goal was…PF-QII Analysis of Deep Brain Stimulation versus Levodopa-carbidopa Intestinal Gel: Real-world Differences in Patient Characteristics and Quality of Life Outcomes
Objective: To evaluate differences in demographics, disease characteristics, quality of life (QOL), and caregiver burden (CB) between deep brain stimulation (DBS) and levodopa-carbidopa intestinal gel…Temporal properties of resting-state functional MRI are associated with ON/OFF levodopa MDS-UPDRS III scores in patients with Parkinson’s disease
Objective: To explore the relationship between temporal resting-state functional magnetic resonance imaging (fMRI) properties and ON/OFF Levodopa motor performance scores in patients with Parkinson's disease…
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