Classifying carriers of the G2019S mutation in the LRRK2 gene using MRI radiomics analysis
Objective: To use radiomics approach based on conventional MRI to classify carriers of LRRK2 mutation among non-manifesting first degree relatives of patients with PD. Background:…Clinical phenotype analysis of Parkinson’s disease associated with LRRK2 variants in Chinese Han population
Objective: Our study aimed to compare motor and non-motor symptoms, imaging features and molecular markers of patients with Parkinson’s disease (PD) who are carriers of…Listen to the heart: Do loud vagal rhythms disharmonize the autonomic symphony in Parkinson’s disease patients with the LRRK2 mutation?
Objective: Assessment of cardiac autonomic function through standard and novel features of heart rate variability (HRV) in individuals who carry the G2019S mutation in the…Evaluation of the relationship between Leucine-rich repeat kinase 2 (LRRK2) S1647T variants and smoking with risk of Parkinson’s Disease in the Singapore population
Objective: To investigate whether cigarette smoking influences the relationship between S1647T variants and risk of PD in the Singapore population. Background: Case-control studies in southern…Objective and quantifiable assessment of sleep in patients with Parkinson’s disease using a wearable sensor
Objective: To explore the feasibility of using a body-fixed sensor (BFS) to assess sleep disturbances in patients with Parkinson's disease (PD), carriers and non-carriers of…Resistance to Parkinson’s disease among LRRK2 mutation carriers is associated with higher plasma levels of urate but not its purine precursors
Objective: To determine whether plasma purine concentrations differ between people with Parkinson's disease (PD) and matched controls among carriers of pathogenic mutations in Leucine-Rich Repeat…Validation of protein phosphatases that regulate the LRRK2 phosphorylation cycle
Objective: To identify and validate candidate phosphatases regulating the LRRK2 phosphorylation cycle. Background: Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are one…Comparison of thermal sensation and pain thresholds in LRRK2 carriers and non carriers with Parkinson’s disease
Objective: To compare between clinical findings and quantitative sensory testing (QST) data in patients with Parkinson's disease (PD) positive and negative for mutations in LRKK2.…Molecular Genetics and Functional Studies of LRRK2 Gene Variations in Parkinson’s Disease
Objective: To evaluate the function role of ROC domain in the brains of LRRK2 transgenic mice model and normal control mice. Background: Mutations in leucine-rich…PD associated with GBA and LRRK2 mutations: Genotype-phenotype correlation
Objective: To study differences in disease characteristics in PD associated with 1 or 2 mutations in the most common PD-associated genes in the Ashkenazi Jewish…
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