LRRK2 Mutation in a Patient with NMDA and GAD 65 Antibodies
Objective: To describe case of a patient who presented with a history of autoimmune encephalitis with NMDA receptor and GAD 65 antibodies positive in cerebrospinal…Alterations of Plasma Membrane in Parkinson’s disease LRRK2 I1371V iPSC derived Astrocytes contribute to the vulnerability of the niche cells to Extracellular α-Synuclein
Objective: This study investigates the impact of LRRK2 I1371V mutation on astrocyte plasma membrane dynamics & its association with extracellular α-synuclein using astrocytes derived from…Unraveling the Genetic Architecture of Progressive Supranuclear Palsy in East Asians
Objective: We aim to elucidate the genetic architecture of progressive supranuclear palsy (PSP) in East Asians through whole-exome sequencing in a multi-center study in Taiwan.…Patient-specific Vascularized Midbrain Assembloids with Microglia show Altered Neuroinflammatory Phenotypes in Parkinson’s Disease
Objective: This study aims to develop patient-specific vascularized midbrain assembloids incorporating microglia to better model the neuroinflammatory environment of Parkinson’s disease (PD). By integrating vascular…Atypical Parkinsonism with LRRK2 Mutation Presenting as Multiple System Atrophy
Objective: We describe a rare case of atypical parkinsonism associated with leucine-rich repeat kinase 2 (LRRK2) gene mutation presenting with clinical features suggestive of multiple…Interrogating GCase Activity in Human Monocytes Isolated from Parkinson’s Disease Patients Carrying the Asian LRRK2 G2385R and R1628P Variants
Objective: To compare Glucocerebrosidase-1 (GCase) activity in human monocytes of manifesting LRRK2 G2385R, R1628P, and double-variant carriers vs. idiopathic Parkinson’s disease (iPD) and healthy controls…A Multidimensional Biomarker Panel for The Early Detection of Parkinson’s Disease
Objective: To explore the potential of a multidimensional biomarker panel integrating motor, non-motor, biochemical, metabolic, genetic, and neuroimaging biomarkers to increase sensitivity and specificity of…Prevalence and Local Ancestry of LRRK2 p.Q1111H in Latin American Cohort
Objective: To expand upon previous work assessing the prevalence of the LRRK2 p.Q1111H variant in Latin America and implement local ancestry analysis to assess ancestral…Smartphone-based digital assessments in the LUMA trial of BIIB122 for early-stage Parkinson’s disease
Objective: To evaluate the sensitivity of routine smartphone-based performance assessments in the free-living environment as part of a randomized clinical trial in Parkinson’s disease (PD).…Inflammatory profile in LRRK2-associated prodromal and clinical PD:a cross-sectional study
Objective: To investigate the peripheral inflammatory cytokine levels and their associations with clinical severity, dopaminergic presynaptic degeneration in asymptomatic carriers and PD patients with LRRK2 mutation.To investigate…
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