Phase 1 and 1b Pharmacodynamic Data Support Central Modulation of Lysosomal Pathways With BIIB122/DNL151, a LRRK2 Kinase Inhibitor: Insights for the LUMA Trial
Objective: Evaluate the effects of BIIB122/DNL151 treatment on CSF levels of pRab10, a biomarker of CNS LRRK2 modulation, in a Phase 1 study in healthy…Impact of Constipation on Motor and Non-Motor Symptoms in G2019s Lrrk2 Parkinson’s Disease A Retrospective Study
Objective: This study aimed to investigate the association between constipation and the severity of motor and non-motor symptoms in PD patients with the G2019S LRRK2…Incidence and Associated Factors for Phenoconversion of Parkinson’s Disease in the Chinese Community Older Adults with LRRK2 G2385R and R1628P Variants
Objective: To investigate the 10-year accumulated incidence and associated factors for phenoconversion of Parkinson’s disease (PD) in community older adults carrying LRRK2 G2385R or/and R1628P variants. Background: Previous…LRRK2 I1371V Mutation Induces ER Stress, Mitochondrial Dysfunction, and Impaired Mitophagy in Parkinson’s Disease Astrocytes
Objective: This study examines the pathogenic effect of the LRRK2 I1371V mutation on mitochondrial dysfunction, as a result of ER calcium dysregulation, and impaired mitophagy…Distinct roles of PARK2, PINK1, and LRRK2 in neuroinflammation: resistance and susceptibility in immune-mediated mouse models
Objective: To investigate the impact of PARK2, PINK1, and LRRK2 deficiency on neuroinflammation in aging, using immune-mediated mouse models. Background: Emerging evidence links mitophagy-related genes, including PARK2 (PARKIN), PINK1, and LRRK2, to immune…LRRK2 Mutation in a Patient with NMDA and GAD 65 Antibodies
Objective: To describe case of a patient who presented with a history of autoimmune encephalitis with NMDA receptor and GAD 65 antibodies positive in cerebrospinal…Alterations of Plasma Membrane in Parkinson’s disease LRRK2 I1371V iPSC derived Astrocytes contribute to the vulnerability of the niche cells to Extracellular α-Synuclein
Objective: This study investigates the impact of LRRK2 I1371V mutation on astrocyte plasma membrane dynamics & its association with extracellular α-synuclein using astrocytes derived from…Unraveling the Genetic Architecture of Progressive Supranuclear Palsy in East Asians
Objective: We aim to elucidate the genetic architecture of progressive supranuclear palsy (PSP) in East Asians through whole-exome sequencing in a multi-center study in Taiwan.…Patient-specific Vascularized Midbrain Assembloids with Microglia show Altered Neuroinflammatory Phenotypes in Parkinson’s Disease
Objective: This study aims to develop patient-specific vascularized midbrain assembloids incorporating microglia to better model the neuroinflammatory environment of Parkinson’s disease (PD). By integrating vascular…Atypical Parkinsonism with LRRK2 Mutation Presenting as Multiple System Atrophy
Objective: We describe a rare case of atypical parkinsonism associated with leucine-rich repeat kinase 2 (LRRK2) gene mutation presenting with clinical features suggestive of multiple…
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