Plasma transferrin level correlates with the tremor-dominant phenotype of Parkinson’s disease
Objective: To examine plasma iron metabolism related indicators in patients with Parkinson’s disease (PD) and investigate the mechanism underlying the tremor-dominant phenotype of PD. Background:…Longitudinal development of nigral iron load in Parkinson’s Disease
Objective: We for the first time investigated longitudinal changes of nigral iron load in Parkinson’s disease (PD) measured by Quantitative Susceptibility Mapping (QSM), a highly…Alpha-synucleinopathy and mitochondrial dysfunction in a cell based model of neurodegeneration: Implications in the pathogenesis of sporadic Parkinson’s disease
Objective: To elucidate the role of α-synuclein, parkin and mitochondria in a cell-based model of neurodegeneration relevant to Parkinson's disease pathogenesis. Background: The suggested mechanisms…Alpha-synuclein protein homeostasis and oligomerization in iron-overloaded cells expressing mutant HFE
Objective: Study the direct and indirect effects of iron overload on alpha synuclein homeostasis in a genetic model of hemochromatosis (HFE) Background: Parkinson’s disease (PD)…Dystonia due to bilateral caudate hemorrhage associated with a COL4A1 mutation
Objective: Pathogenic mutations of COL4A1 are associated with young-onset stroke and porencephaly. We present a case of a 32-year-old female patient with juvenile onset right hand…Elemental fingerprint as a cerebrospinal fluid biomarker for the diagnosis of Parkinson’s disease
Objective: To employ a combination of elemental concentrations in the cerebrospinal fluid (CSF) to identify a diagnostic biomarker profile differentiating patients with idiopathic Parkinson´s disease…High-Pass Filtered Phase MR Imaging to Detect Longitudinal Motor Associations of Iron Accumulation in Parkinson’s Disease
Objective: To assess whether longitudinal changes in deep grey matter nuclei iron content are associated with declining motor function in Parkinson’s disease over a period…The Roles of Diet, Exercise, & Supplements in Parkinson’s Disease Progression
Objective: The goal of this ongoing study is to describe whether modifiable aspects of lifestyle are associated with PD symptom severity and progression. Background: Epidemiological…Serum soluble transferrin receptor levels correlate with the Hoehn & Yahr stage of Parkinson disease progression
Objective: To test whether levels of soluble transferrin receptor (sTfR) in the serum of Parkinson disease (PD) patients are correlated with the progression of the disease…Bristle hair may point to hereditary spastic paraplegia type SPG35/ FAHN
Objective: Finding new phenotypic features or biomarkers in hereditary spastic paraplegia type SPG35 / Fatty Acid Hydroxylase-associated Neurodegeneration (FAHN) to help clinicians to identify this…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.