Caudal posterior substantia nigra iron increases longitudinally in Parkinson’s disease
Objective: To investigate spatial patterns and temporal evolution of substantia nigra (SN) iron accumulation in Parkinson’s disease (PD) using quantitative susceptibility mapping (QSM), an indirect…In vivo increased striatal iron deposition in Parkinson’s Disease Dementia and Dementia with Lewy Body
Objective: To evaluate iron deposition with susceptibility weighted imaging (SWI) MRI in the basal ganglia of patients affected by Parkinson’s Disease Dementia (PDD) and Dementia…Quantification of regional iron content with Susceptibility Weighted Imaging in Huntington Disease Expansion Gene Carriers
Objective: To assess brain iron content measured with SWI-MRI in HD gene expansion carriers (HDGECs). Background: Huntington’s Disease (HD) results in extensive neuronal cell loss,…Safety of Iron Chelation in Patients with Brain Iron Overload
Objective: To assess the safety of iron chelation in the treatment of regional brain iron overload. Background: Excess brain iron is evident in neurodegenerative diseases…Iron Supplementation for the Treatment of Restless Legs Syndrome – A Systematic Review and Meta-Analysis
Objective: To gather the evidence for the efficacy and safety of iron supplementation for restless legs syndrome (RLS). Background: Iron supplementation is used for the…Nigral Iron Load as Diagnostic Parameter in Parkinson’s Disease
Objective: The aim of our study was to determine the diagnostic value of nigral iron depositions in PD, measured by iron specific MRI-techniques. Background: Nigral…PBT434 prevents the accumulation of glial cell inclusions and insoluble alpha-synuclein in a mouse model of Multiple System Atrophy
Objective: To evaluate PBT434 in a transgenic mouse model of multiple system atrophy (MSA) Background: PBT434 is a novel quinazolinone inhibitor of iron-mediated protein accumulation…Seasonal Fluctuation in a Chinese cohort of patients with idiopathic Restless Legs Syndrome
Objective: To evaluate incidence and characteristics of seasonal fluctuation in a Chinese cohort of patients with idiopathic RLS in order to differentiate possible subtypes and…Plasma transferrin level correlates with the tremor-dominant phenotype of Parkinson’s disease
Objective: To examine plasma iron metabolism related indicators in patients with Parkinson’s disease (PD) and investigate the mechanism underlying the tremor-dominant phenotype of PD. Background:…Longitudinal development of nigral iron load in Parkinson’s Disease
Objective: We for the first time investigated longitudinal changes of nigral iron load in Parkinson’s disease (PD) measured by Quantitative Susceptibility Mapping (QSM), a highly…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.