Improving the design of clinical trials in early-stage Parkinson’s disease by using the estimand framework
Objective: To show how the estimand framework can be used to improve design of clinical trials testing treatments in early-stage Parkinson’s disease (PD). Background: The…Effect of exercise on brain metabolism and energetics in PD
Objective: To identity the effect of exercise on brain metabolism and energetics in PD using PET/MR imaging. Background: Aerobic exercise slows PD progression as reflected…NONINVASIVE BRAINSTEM MODULATION FOR THE TREATMENT OF NONMOTOR SYMPTOMS IN PARKINSON’S DISEASE: A RANDOMIZED CONTROLLED TRIAL AND OPEN LABEL EXTENSION STUDY
Objective: A multi-site double-blinded pivotal randomized controlled trial (RCT) with an open label extension (OLE) study has been initiated to evaluate the safety and efficacy…Time-to-event approach mitigates the treatment masking effect of symptomatics on MDS-UPDRS Part III
Objective: To assess whether a time-to-event (TTE) approach may mitigate the masking effect of changing symptomatic therapy on Movement Disorders Society–Unified Parkinson’s Disease (PD) Rating…Parkinson`s disease in Pandemic Covid
Objective: SARS-CoV2 infection invades the brain through ACE2 receptors or the cytotoxic aggregation of proteins, including α-synuclein.Studies are uncertain on the risk of COVID and…Yoga for Functional Neurological Disorder (FND) – A Case Study
Objective: To describe key components of a yoga program for an individual with FND and evaluate feasibility and efficacy. Background: FND is the second most…Liraglutide once daily versus placebo in Parkinson’s disease: a randomized, double-blind, placebo-controlled trial
Objective: To test safety and efficacy of the glucagon-like peptide 1 (GLP-1) agonist liraglutide in idiopathic Parkinson’s disease (PD). Background: Insulin resistance (IR) may play…A motor-cognitive intervention impacts daily-living gait and activity in Parkinson’s disease fallers differently than a motor intervention: analysis using a machine learning approach
Objective: Applying machine learning (ML) to identify if there were clusters of daily-living gait and physical activity measures that differed among responders to the two…Patient Advisory Boards: A Model for Patient Engagement in Parkinson’s Disease Comparative Effectiveness Research
Objective: To build a replicable, sustainable model of patient engagement in Parkinson’s disease (PD) comparative effectiveness research (CER) at academic research centers through patient advisory…Transauricular Vagus Nerve Stimulation (taVNS) for mild to moderate Parkinson’s Disease (PD)
Objective: We evaluated feasibility, safety, and preliminary efficacy of taVNS for motor and non-motor symptoms in mild to moderate PD. Background: Neuronal loss in the…
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